Bonner F W, King L J, Parke D V
Chem Biol Interact. 1979 Oct;27(2-3):343-51. doi: 10.1016/0009-2797(79)90137-6.
The effect of repeated parenteral administration of cadmium (0.75, 1.5 and 3.0 mg/kg) on tissue disposition and urinary excretion of cadmium, zinc, copper and iron has been studied in the male rat. Cadmium, zinc and copper accumulated in liver and kidney, but the concentration of iron did not alter significantly. The kidney weight relative to body weight showed a dose-related increase in weight of 25--65%. Excretion of cadmium in the urine increased directly with dosage and the increase was most significant when kidney damage had probably occurred. Administration of cadmium also resulted in dose-related increases in the urinary excretion of zinc, copper and iron. The cadmium concentration of blood increased with dosage of cadmium, and the plasma concentrations of zinc and copper were also raised but plasma iron concentration was diminished.
在雄性大鼠中研究了重复肠胃外注射镉（0.75、1.5和3.0毫克/千克）对镉、锌、铜和铁的组织分布及尿排泄的影响。镉、锌和铜在肝脏和肾脏中蓄积，但铁的浓度没有显著变化。相对于体重而言，肾脏重量呈现出与剂量相关的增加，增幅为25%至65%。尿中镉的排泄量随剂量直接增加，当可能已发生肾脏损伤时增加最为显著。镉的给药还导致锌、铜和铁的尿排泄量出现与剂量相关的增加。血液中的镉浓度随镉剂量增加而升高，血浆中锌和铜的浓度也升高，但血浆铁浓度降低。
