Wang Yue, Li Jun, Wu Jianming, Gu Shihong, Hu Huishu, Cai Rongjuan, Wang Man, Zou Yue
Institute of Shanghai Oriental Beauty Valley, Shanghai Institute of Technology, Shanghai, People's Republic of China.
School of Perfume and Aroma Technology, Shanghai Institute of Technology, Shanghai, People's Republic of China.
Clin Cosmet Investig Dermatol. 2023 Sep 21;16:2623-2635. doi: 10.2147/CCID.S415787. eCollection 2023.
Sensitive scalp is one of the most frequent complaints related to sensitive skin syndrome, characterized by unpleasant sensory reactions in the absence of visible signs of inflammation. In this study, the effects of topical application of postbiotic Himalaya-derived and ferment complex (SLFC) on the bacterial and fungal scalp microbiome at the taxonomic level and alleviation of sensitive skin syndrome were investigated.
Firstly, healthy female participants (aged 30-45) were classified into a healthy scalp group and a sensitive scalp group based on the questionnaire. Thereafter, topical application of SLFC on sensitive scalp as well as scalp microbiome was evaluated, with the difference in the distribution of microbial taxa between healthy and sensitive scalp communities was assessed using 16S rRNA and ITS1 sequencing analysis. In addition, the effect of SLFC on scalp microbiome at the species level for , and was evaluated by the qPCR assessment.
After treatment with SLFC for 28 days, the abundance of , and in the sensitive scalp group was highly significantly increased ( < 0.001), while the abundance of and was highly significantly decreased ( < 0.001). Furthermore, the self-assessment questionnaire indicated a syndrome alleviation effect of 100% after 28 days with a twice-daily application of the SLFC.
The obtained results would help to better understand the microbial community of the sensitive scalp and provide useful information on utilization of SLFC for maintaining a healthy scalp and modulating the scalp microbiome.
头皮敏感是与敏感皮肤综合征相关的最常见主诉之一，其特征是在没有明显炎症迹象的情况下出现不适的感觉反应。在本研究中，研究了局部应用源自喜马拉雅山的后生元和发酵复合物（SLFC）对头皮细菌和真菌微生物群在分类水平上的影响以及对敏感皮肤综合征的缓解作用。
首先，根据问卷将健康女性参与者（年龄30 - 45岁）分为健康头皮组和敏感头皮组。此后，评估了SLFC在敏感头皮上的局部应用以及头皮微生物群，使用16S rRNA和ITS1测序分析评估健康和敏感头皮群落之间微生物分类群分布的差异。此外，通过qPCR评估来评估SLFC在物种水平上对头皮微生物群中[具体物种]的影响。
用SLFC治疗28天后，敏感头皮组中[具体物种]的丰度显著升高（P < 0.001），而[另外两种物种]的丰度显著降低（P < 0.001）。此外，自我评估问卷显示，每天两次应用SLFC 28天后，综合征缓解效果达100%。
所得结果将有助于更好地了解敏感头皮的微生物群落，并为利用SLFC维持健康头皮和调节头皮微生物群提供有用信息。
