Department of Biological Sciences, Indian Institute of Science Education and Research Bhopal, Bhopal, India.
L'Oréal Research & Innovation, Aulnay-sous-Bois, France.
Front Cell Infect Microbiol. 2018 Oct 4;8:346. doi: 10.3389/fcimb.2018.00346. eCollection 2018.
Several scalp microbiome studies from different populations have revealed the association of dandruff with bacterial and fungal dysbiosis. However, the functional role of scalp microbiota in scalp disorders and health remains scarcely explored. Here, we examined the bacterial and fungal diversity of the scalp microbiome and their potential functional role in the healthy and dandruff scalp of 140 Indian women. and emerged as the core bacterial species, where the former was associated with a healthy scalp and the latter with dandruff scalp. Along with the commonly occurring species ( and ) on the scalp, a strikingly high association of dandruff with yet uncharacterized species was observed in the core mycobiome. Functional analysis showed that the fungal microbiome was enriched in pathways majorly implicated in cell-host adhesion in the dandruff scalp, while the bacterial microbiome showed a conspicuous enrichment of pathways related to the synthesis and metabolism of amino acids, biotin, and other B-vitamins, which are reported as essential nutrients for hair growth. A systematic measurement of scalp clinical and physiological parameters was also carried out, which showed significant correlations with the microbiome and their associated functional pathways. The results point toward a new potential role of bacterial commensals in maintaining the scalp nutrient homoeostasis and highlights an important and yet unknown role of the scalp microbiome, similar to the gut microbiome. This study, therefore, provides new perspectives on the better understanding of the pathophysiology of dandruff.
几项来自不同人群的头皮微生物组研究表明，头皮屑与细菌和真菌失调有关。然而，头皮微生物组在头皮疾病和健康中的功能作用仍鲜有探索。在这里，我们研究了 140 名印度女性健康和有头皮屑头皮的头皮微生物组的细菌和真菌多样性及其潜在的功能作用。 和 是核心细菌物种，前者与健康的头皮有关，后者与头皮屑头皮有关。除了头皮上常见的 物种（ 和 ）外，在核心真菌组中还观察到与尚未表征的 物种与头皮屑的强烈关联。功能分析表明，真菌微生物组在头皮屑头皮中与细胞-宿主黏附相关的途径中富集，而细菌微生物组则显示出与氨基酸、生物素和其他 B 族维生素的合成和代谢相关的途径的显著富集，这些物质被报道为头发生长的必需营养素。还对头皮临床和生理参数进行了系统测量，这些参数与微生物组及其相关功能途径之间存在显著相关性。研究结果表明，细菌共生菌在维持头皮营养稳态方面可能具有新的潜在作用，并强调了头皮微生物组的重要而未知的作用，类似于肠道微生物组。因此，这项研究为更好地理解头皮屑的病理生理学提供了新的视角。
