Elijovich Fernando, Kirabo Annet, Laffer Cheryl L
Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN.
Hypertension. 2024 Mar;81(3):456-467. doi: 10.1161/HYPERTENSIONAHA.123.17951. Epub 2023 Sep 28.
Race is a social construct, but self-identified Black people are known to have higher prevalence and worse outcomes of hypertension than White people. This may be partly due to the disproportionate incidence of salt sensitivity of blood pressure in Black people, a cardiovascular risk factor that is independent of blood pressure and has no proven therapy. We review the multiple physiological systems involved in regulation of blood pressure, discuss what, if anything is known about the differences between Black and White people in these systems and how they affect salt sensitivity of blood pressure. The contributions of genetics, epigenetics, environment, and social determinants of health are briefly touched on, with the hope of stimulating further work in the field.
种族是一种社会建构，但众所周知，自我认定为黑人的人群比白人患高血压的患病率更高，预后更差。这可能部分归因于黑人中血压盐敏感性的发病率不成比例，这是一种独立于血压且尚无经证实治疗方法的心血管危险因素。我们回顾了参与血压调节的多个生理系统，讨论了关于黑人和白人在这些系统中的差异以及它们如何影响血压盐敏感性的已知情况（如果有的话）。简要提及了遗传学、表观遗传学、环境和健康的社会决定因素的作用，希望能激发该领域的进一步研究。
