Department of Clinical and Community Pharmacy, College of Medicine and Health Sciences, An-Najah National University, 44839, Nablus, Palestine.
Clinical Research Center, An-Najah National University Hospital, 44839, Nablus, Palestine.
J Transl Med. 2022 Feb 11;20(1):83. doi: 10.1186/s12967-022-03293-y.
Significant links between the microbiota and human health have emerged in the last 20 years. A correlation has recently been demonstrated between changes in the gut microbiota and the development of cancer. This study aimed to use bibliometric analysis of the published gut microbiome and cancer literature to present the research status and summarize the hotspots for frontier studies.
A literature search for research on the gut microbiome and cancer research from 2001 to 2020 was conducted using the Scopus database on 20 March 2021. VOSviewer software (version 1.6.16) was used to perform the visualization analysis.
From 2001 to 2020, a total of 2061 publications were retrieved. Annual publication output grew from 10 in 2001 to 486 in 2020. The USA had the largest number of publications, making the largest contribution to the field (n = 566, 27.46%). Before 2016, most studies focused on the 'effect of probiotics on cancer'. The latest trends showed that 'microbiota composition and gene expression' and 'host-microbiome interaction in cancer immunotherapy' would be more concerned more widely in the future.
Research on 'microbiota composition and gene expression' and 'host-microbiome interaction in cancer immunotherapy' will continue to be the hotspot. Therefore, this study provides the trend and characteristics of the literature on the gut microbiota and cancer literature, which provided a useful bibliometric analysis for researchers to conduct further research.
在过去的 20 年中，人们已经发现微生物组与人类健康之间存在着重要的联系。最近已经证明，肠道微生物群的变化与癌症的发展之间存在相关性。本研究旨在通过对已发表的肠道微生物组和癌症文献进行文献计量分析，呈现研究现状，并总结前沿研究的热点。
于 2021 年 3 月 20 日使用 Scopus 数据库对 2001 年至 2020 年肠道微生物组与癌症研究相关的文献进行检索。使用 VOSviewer 软件（版本 1.6.16）进行可视化分析。
从 2001 年至 2020 年，共检索到 2061 篇出版物。年度出版物产出从 2001 年的 10 篇增长到 2020 年的 486 篇。美国发表的文章数量最多，对该领域的贡献最大（n=566，27.46%）。在 2016 年之前，大多数研究集中在“益生菌对癌症的影响”上。最新趋势表明，未来将更加关注“微生物群组成和基因表达”以及“癌症免疫治疗中的宿主-微生物群相互作用”。
关于“微生物群组成和基因表达”以及“癌症免疫治疗中的宿主-微生物群相互作用”的研究将继续成为热点。因此，本研究提供了肠道微生物组和癌症文献的文献计量分析趋势和特征，为研究人员进行进一步研究提供了有用的参考。
