Sun Chunxiao, Muraoka Yuki, Ishihara Kenji, Morooka Satoshi, Akada Masahiro, Hata Masayuki, Tsujikawa Akitaka
Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto City, Kyoto, Japan.
Retin Cases Brief Rep. 2025 Jan 1;19(1):23-27. doi: 10.1097/ICB.0000000000001500.
To describe a rare case of Epstein-Barr virus (EBV)-positive primary vitreoretinal lymphoma in an immunosuppressed patient.
Observational case report.
A 64-year-old man under immunosuppressive therapy for rheumatic arthritis was referred for 2 months of blurred vision and decreased visual acuity in the right eye. Only mutton-fat keratic precipitates and mild vitreous opacity were found in the right eye without (sub)retinal or sub-retinal pigment epithelial lesions. Vitreous biopsy and systemic workup suggested the diagnosis of primary vitreoretinal lymphoma of diffuse large B-cell lymphoma subform. Neoplastic cells stained positive for EBV antigens, EBV-encoded small RNA, and Epstein-Barr nuclear antigen 2, consistent with EBV-positive diffuse large B-cell lymphoma. Intravitreal methotrexate was effective in improving ocular symptoms.
The case provided evidence on the association of EBV infection with primary vitreoretinal lymphoma.
