眼内炎症患者中 Epstein-Barr 病毒的流行情况。
Prevalence of Epstein-Barr Virus in Patients with Intraocular Inflammation.
机构信息
Department of Ophthalmology and Vision Science, University of California, Davis, Sacramento, California, USA.
F.I. Proctor Foundation, San Francisco, California, USA.
出版信息
Ocul Immunol Inflamm. 2023 Jul;31(5):978-980. doi: 10.1080/09273948.2022.2075760. Epub 2022 Jun 16.
The relationship between Epstein-Barr virus (EBV) infection and uveitis is unclear. We conducted an observational cross-sectional study to determine the prevalence of EBV in uveitis and to describe the clinical features of EBV-positive uveitis cases. This study was carried out at the F.I. Proctor Foundation at the University of California, San Francisco. All patients with suspected infectious uveitis who underwent unbiased metagenomic deep sequencing (MDS) were included. Demographics, testing information, and clinical features were documented. Eleven out of 288 patients with suspected infectious uveitis had EBV detected by RNA-seq in intraocular fluid. The prevalence of EBV in uveitis in our study sample is 4%. Three out of 11 EBV-positive eyes (27%) were found to have biopsy-proven vitreoretinal lymphoma. Future studies are needed to determine if EBV may drive the development of vitreoretinal lymphoma and if its presence should heighten the suspicion of vitreoretinal lymphoma.
EB 病毒（EBV）感染与葡萄膜炎之间的关系尚不清楚。我们进行了一项观察性横断面研究，以确定 EBV 在葡萄膜炎中的流行率，并描述 EBV 阳性葡萄膜炎病例的临床特征。这项研究是在加利福尼亚大学旧金山分校的 F.I. Proctor 基金会进行的。所有疑似感染性葡萄膜炎并接受无偏倚宏基因组深度测序（MDS）的患者均被纳入。记录了人口统计学、检测信息和临床特征。在 288 例疑似感染性葡萄膜炎患者中，有 11 例通过眼内液 RNA 测序检测到 EBV。在我们的研究样本中，葡萄膜炎中 EBV 的患病率为 4%。在 11 例 EBV 阳性眼（27%）中，有 3 例经活检证实为玻璃体细胞淋巴瘤。需要进一步的研究来确定 EBV 是否可能导致玻璃体细胞淋巴瘤的发生，以及其存在是否应增加对玻璃体细胞淋巴瘤的怀疑。
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