从红树林内生真菌GXNU TH4b中分离得到的两种新型聚酮衍生物。
Two new polyketone derivatives from the mangrove endophytic fungus GXNU TH4b.
作者信息
Ju Shichao, Bo Xianglong, Wu Furong, Tan Meijing, Song Zisuo, He Fan, Li Wenjun, Wei Youquan, Xu Weifeng, Yang Ruiyun, Huang Xishan
机构信息
State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, College of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, P. R. China.
出版信息
Nat Prod Res. 2024 Oct 7:1-6. doi: 10.1080/14786419.2024.2411366.
Two new polyketones, exserone B () and cytosporone F (), along with three known metabolites, were isolated from the mangrove endophytic fungus TH4b. The structures of and were determined by detailed NMR, and MS spectroscopic data. The absolute configurations of and were determined by single crystal X-ray diffraction analysis and the combination of experimental ECD and computational ECD, respectively. Compounds have strong inhibitory activity against citrus Psyllid () with 95.4% and 93.7% lethal at 1000 mg/kg.
从红树林内生真菌TH4b中分离出两种新的聚酮化合物，即外生菌素B（）和孢丝菌素F（），以及三种已知的代谢产物。通过详细的核磁共振（NMR）和质谱（MS）光谱数据确定了和的结构。分别通过单晶X射线衍射分析以及实验性电子圆二色谱（ECD）与计算性ECD相结合的方法确定了和的绝对构型。化合物对柑橘木虱（）具有很强的抑制活性，在1000mg/kg时致死率分别为95.4%和93.7%。
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