Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, CA, 90095, USA.
Department of Gastrointestinal Surgery, Huizhou Municipal Central Hospital, Huizhou, Guangdong, 516001, People's Republic of China.
Eur J Med Res. 2023 Sep 28;28(1):385. doi: 10.1186/s40001-023-01342-w.
Platelets play a crucial role in cancer blood metastasis. Various cancer-related factors such as Toll-like receptors (TLRs), adenosine diphosphate (ADP) or extracellular matrix (ECM) can activate these small particles that function in hemostasis and thrombosis. Moreover, platelets induce Epithelial Mesenchymal Transition (EMT) to promote cancer progression and invasiveness. The activated platelets protect circulating tumor cells from immune surveillance and anoikis. They also mediate tumor cell arrest, extravasation and angiogenesis in distant organs through direct or indirect modulation, creating a metastatic microenvironment. This review summarizes the recent advances and progress of mechanisms in platelet activation and its interaction with cancer cells in metastasis.
血小板在癌症血液转移中起着至关重要的作用。各种与癌症相关的因素，如 Toll 样受体（TLRs）、二磷酸腺苷（ADP）或细胞外基质（ECM），可以激活这些在止血和血栓形成中发挥作用的小颗粒。此外，血小板诱导上皮间质转化（EMT），促进癌症的进展和侵袭性。激活的血小板保护循环肿瘤细胞免受免疫监视和失巢凋亡。它们还通过直接或间接调节，介导肿瘤细胞在远处器官的阻滞、渗出和血管生成，形成转移的微环境。本综述总结了血小板激活及其与转移癌细胞相互作用的机制的最新进展和研究进展。
