Mitermite Morgane, Elizari Jose Maria Urtasun, Ma Ruoyao, Farrell Damien, Gordon Stephen V
UCD School of Veterinary Medicine, University College Dublin, Dublin, Ireland.
Faculty of Science, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
Ir Vet J. 2023 Sep 28;76(Suppl 1):26. doi: 10.1186/s13620-023-00257-6.
Here we provide a summary of a plenary lecture delivered on Mycobacterium bovis, the bovine TB bacillus, at the M. bovis 2022 meeting held in Galway, Ireland, in June 2022. We focus on the analysis of genetic differences between M. bovis and the human pathogen Mycobacterium tuberculosis as a route to gain knowledge on what makes M. bovis function as an animal pathogen. We provide a brief historical background around M. bovis and comparative virulence experiments with M. tuberculosis, before moving to what we have learned from the studies of the M. bovis genome sequence. We discuss the need to translate knowledge on the molecular basis of virulence in M. bovis into improved control of bovine tuberculosis.
本文提供了2022年6月在爱尔兰戈尔韦举行的牛分枝杆菌2022会议上，关于牛结核杆菌——牛分枝杆菌的全会演讲总结。我们着重分析牛分枝杆菌与人类病原体结核分枝杆菌之间的基因差异，以此作为了解牛分枝杆菌作为动物病原体的作用机制的途径。在阐述从牛分枝杆菌基因组序列研究中获得的知识之前，我们先简要介绍牛分枝杆菌的历史背景以及与结核分枝杆菌的比较毒力实验。我们讨论了将关于牛分枝杆菌毒力分子基础的知识转化为改善牛结核病防控措施的必要性。
