Benedict Kaitlin, Gold Jeremy A W, Beekmann Susan E, Polgreen Philip M, Toda Mitsuru, Smith Dallas J
Mycotic Diseases Branch, Division of Foodborne, Waterborne, and Environmental Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
Open Forum Infect Dis. 2023 Sep 12;10(9):ofad468. doi: 10.1093/ofid/ofad468. eCollection 2023 Sep.
In a survey of 523 infectious disease specialists, a moderate to high percentage reported using any antifungal therapeutic drug monitoring (TDM) during itraconazole (72%), posaconazole (72%), and voriconazole (90%) treatment, and a low to moderate percentage reported using any antifungal TDM during prophylaxis (32%, 55%, and 65%, respectively). Long turnaround times for send-out TDM testing and logistical difficulties were frequent barriers.
在一项对523名传染病专家的调查中，有中等至高比例的专家报告在使用伊曲康唑（72%）、泊沙康唑（72%）和伏立康唑（90%）治疗期间进行了任何抗真菌治疗药物监测（TDM），而在预防期间进行任何抗真菌TDM的专家比例为低至中等（分别为32%、55%和65%）。送检TDM检测周转时间长和后勤困难是常见的障碍。
