2019 - 2021年美国接受伊曲康唑、泊沙康唑或伏立康唑治疗的住院患者中抗真菌治疗药物监测的低比率
Low Rates of Antifungal Therapeutic Drug Monitoring Among Inpatients Who Received Itraconazole, Posaconazole, or Voriconazole, United States, 2019-2021.
作者信息
Benedict Kaitlin, Gold Jeremy A W, Toda Mitsuru, Thompson George R, Wiederhold Nathan P, Smith Dallas J
机构信息
Mycotic Diseases Branch, Division of Foodborne, Waterborne, and Environmental Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Department of Internal Medicine, Division of Infectious Diseases, University of California, Davis Medical Center, Sacramento, California, USA.
出版信息
Open Forum Infect Dis. 2023 Jul 20;10(8):ofad389. doi: 10.1093/ofid/ofad389. eCollection 2023 Aug.
Abstract
Antifungal therapeutic drug monitoring (TDM) is recommended for hospitalized patients receiving itraconazole, posaconazole, or voriconazole for treatment or prophylaxis. In this analysis of hospital-based data, TDM was uncommonly performed (15.8%) in a large cohort of eligible patients, suggesting missed opportunities to avoid subtherapeutic drug levels and minimize toxicity.
摘要
对于接受伊曲康唑、泊沙康唑或伏立康唑治疗或预防的住院患者，建议进行抗真菌治疗药物监测（TDM）。在这项基于医院数据的分析中，在一大批符合条件的患者中，TDM的实施情况并不常见（15.8%），这表明存在错过避免药物水平低于治疗剂量并将毒性降至最低的机会。
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