Heng M C, Kloss S G
Am J Dermatopathol. 1986 Oct;8(5):403-10. doi: 10.1097/00000372-198610000-00006.
We report the clinical and electron-microscopic features of endothelial cell toxicity in patients treated with hyperbaric oxygen for prolonged periods for leg ulcers. The clinical manifestations include the appearance of depressed white areas within the bed of granulation tissue, which correlated with decreased vascularity under light microscopy. Electron-microscopic findings include endothelial cells with serrated nuclear membranes and degenerate mitochondria in the cytoplasm. These changes occurred in all patients subjected to at least 8 weeks of hyperbaric oxygen, even though an intermittent regimen was adopted. The changes reversed after 1-2 weeks of cessation of hyperbaric oxygen.
我们报告了因腿部溃疡接受长时间高压氧治疗的患者内皮细胞毒性的临床和电子显微镜特征。临床表现包括肉芽组织床内出现凹陷的白色区域，这与光学显微镜下血管减少相关。电子显微镜检查结果包括核膜呈锯齿状的内皮细胞以及细胞质中退化的线粒体。这些变化发生在所有接受至少8周高压氧治疗的患者中，即使采用的是间歇性治疗方案。在停止高压氧治疗1 - 2周后，这些变化逆转。
