Ma Dan, Guan Baoyi, Song Luxia, Liu Qiyu, Fan Yixuan, Zhao Lin, Wang Tongxin, Zhang Zihao, Gao Zhuye, Li Siming, Xu Hao
Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Graduate School, Beijing University of Chinese Medicine, Beijing, China.
Front Cardiovasc Med. 2021 Aug 25;8:734514. doi: 10.3389/fcvm.2021.734514. eCollection 2021.
Exosomes in cardiovascular diseases (CVDs) have become an active research field with substantial value and potential. Nevertheless, there are few bibliometric studies in this field. We aimed to visualize the research hotspots and trends of exosomes in CVDs using a bibliometric analysis to help understand the future development of basic and clinical research. The articles and reviews regarding exosomes in the CVDs were culled from the Web of Science Core Collection, and knowledge maps were generated using CiteSpace and VOSviewer software. A total of 1,039 articles were included. The number of exosome articles in the CVDs increased yearly. These publications came from 60 countries/regions, led by the US and China. The primary research institutions were Shanghai Jiao Tong University and Nanjing Medical University. was the journal and co-cited journal with the most studies. We identified 473 authors among which Lucio Barile had the most significant number of articles and Thery C was co-cited most often. After analysis, the most common keywords are myocardium infarction, microRNA and mesenchymal stem cells. Ischemic heart disease, pathogenesis, regeneration, stem cells, targeted therapy, biomarkers, cardiac protection, and others are current and developing areas of study. We identified the research hotspots and trends of exosomes in CVDs using bibliometric and visual methods. Research on exosomes is flourishing in the cardiovascular medicine. Regenerative medicine, exosome engineering, delivery vehicles, and biomarkers will likely become the focus of future research.
心血管疾病（CVDs）中的外泌体已成为一个具有重大价值和潜力的活跃研究领域。然而，该领域的文献计量学研究较少。我们旨在通过文献计量分析可视化心血管疾病中外泌体的研究热点和趋势，以帮助了解基础研究和临床研究的未来发展。从科学网核心合集中筛选出有关心血管疾病中外泌体的文章和综述，并使用CiteSpace和VOSviewer软件生成知识图谱。共纳入1039篇文章。心血管疾病中外泌体文章的数量逐年增加。这些出版物来自60个国家/地区，以美国和中国为首。主要研究机构是上海交通大学和南京医科大学。是研究最多的期刊和共被引期刊。我们确定了473位作者，其中Lucio Barile的文章数量最多，Thery C被共引的次数最多。分析后，最常见的关键词是心肌梗死、微小RNA和间充质干细胞。缺血性心脏病、发病机制、再生、干细胞、靶向治疗、生物标志物、心脏保护等是当前和正在发展的研究领域。我们使用文献计量和可视化方法确定了心血管疾病中外泌体的研究热点和趋势。心血管医学中外泌体的研究正在蓬勃发展。再生医学、外泌体工程、递送载体和生物标志物可能会成为未来研究的重点。
