细胞身份基因和管家基因的调控结构。
Regulatory architecture of cell identity genes and housekeeping genes.
机构信息
Whitehead Institute for Biomedical Research, Cambridge, MA, USA.
Whitehead Institute for Biomedical Research, Cambridge, MA, USA; Massachusetts Institute of Technology, Cambridge, MA, USA.
出版信息
Trends Cell Biol. 2023 Dec;33(12):1010-1013. doi: 10.1016/j.tcb.2023.08.007. Epub 2023 Sep 27.
Abstract
Gene regulation and chromosome architecture are intimately linked. Genes with prominent roles in cell identity are often regulated by clusters of enhancer elements. By contrast, a recent study shows housekeeping genes are often regulated through clustering of promoters. We discuss here new regulatory insights for these two types of genes.
摘要
基因调控和染色体结构密切相关。在细胞身份中起重要作用的基因通常受增强子簇的调控。相比之下，最近的一项研究表明，管家基因通常通过启动子簇的聚类来调节。在这里，我们讨论了这两种类型的基因的新的调控见解。
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