Bonnet M C, Julia J M, Mathieu-Daudé J C, du Cailar J
Ann Fr Anesth Reanim. 1986;5(3):243-8. doi: 10.1016/s0750-7658(86)80151-4.
The effects were studied of normovolaemic haemodilution on postoperative traumatic oedema after surgical repair of craniofacial disjunction (CFD) and on pedicle graft viability after excision of squamous carcinomas of the floor of the mouth (CFM). Fourty patients were studied: twenty operated on for CFD and twenty for CFM. These patients were randomly assigned to the treated or the control groups. The treated ones were operated on under moderate normovolaemic haemodilution induced with a colloid solution (Plasmion). The subsequent haematocrits were 0.29 +/- 0.01 for the CFD group and 0.30 +/- 0.02 for the CFM group. The biometric parameters and the length of the surgical procedures were comparable for the two series. Operative blood loss was less in the treated series (p less than 0.001 for the CFD group and p less than 0.01 for the CFM group), thus needing less blood transfusion (p less than 0.001). The postoperative oedema in the treated CFD series was less (p less than 0.001), although the oncotic pressure and the plasma osmolality were decreased in this series (p less than 0.05). On the other hand, viscosity in the hemodiluted series was significantly decreased in comparison with the control series (p less than 0.001). Graft viability was significantly improved in the treated series (p less than 0.05). Thus, normovolaemic haemodilution was a very useful adjunct in plastic and reconstructive surgery of the face and the mouth. This technique had three advantages: reduction of postoperative traumatic oedema after CFM repair, graft viability improvement after mouth carcinoma excision and blood saving in both procedures.
研究了等容性血液稀释对颅面分离(CFD)手术修复术后创伤性水肿以及对口腔底部鳞状细胞癌(CFM)切除术后带蒂移植物存活能力的影响。研究了40例患者:20例接受CFD手术,20例接受CFM手术。这些患者被随机分为治疗组或对照组。治疗组患者在使用胶体溶液(血浆代用品)诱导的中度等容性血液稀释下进行手术。CFD组随后的血细胞比容为0.29±0.01,CFM组为0.30±0.02。两个系列的生物测量参数和手术时间相当。治疗组的术中失血量较少(CFD组p<0.001,CFM组p<0.01),因此输血需求较少(p<0.001)。治疗的CFD系列术后水肿较轻(p<0.001),尽管该系列的胶体渗透压和血浆渗透压有所降低(p<0.05)。另一方面,与对照组相比,血液稀释系列的粘度显著降低(p<0.001)。治疗组的移植物存活能力显著提高(p<0.05)。因此,等容性血液稀释在面部和口腔整形与重建手术中是一种非常有用的辅助手段。该技术有三个优点:CFM修复术后减少创伤性水肿、口腔癌切除术后提高移植物存活能力以及在这两种手术中节省血液。