Xu Qingqing, Fan Keliang, Wei Dandan, Wang Lulu, Wang Juan, Song Yu, Wang Mian, Zhao Mengzhen, Liu Xiaotian, Huo Wenqian, Li Linlin, Hou Jian, Jing Tao, Wang Chongjian, Mao Zhenxing
Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China.
Teaching and Training Department, Affiliated Hospital of Jiaxing University/ The First Hospital of Jiaxing, 314000 Zhejiang, China.
Ecotoxicol Environ Saf. 2023 Oct 15;265:115524. doi: 10.1016/j.ecoenv.2023.115524. Epub 2023 Sep 28.
Plasma polybrominated diphenyl ethers (PBDE) were used as flame retardants widely, however, epidemiological evidence for the association between PBDEs and type 2 diabetes mellitus (T2DM) is inconsistent. Moreover, the combined effects of PBDEs and blood lipid indicators on impaired fasting glucose (IFG) and T2DM remains largely unknown in rural areas lacking good waste recycling infrastructure.
In this study, a total of 2607 subjects aged 18-79 years were included from the Henan Rural Cohort. Generalized linear and logistic regression models were applied to evaluate the associations of various PBDE pollutants on IFG and T2DM. Quantile g-computation regression and PBDE pollution score created by the adaptive elastic net were applied to evaluate the impact of PBDEs mixtures on IFG and T2DM. Interaction effects of individual PBDE pollutants and blood lipid indicators on IFG and T2DM were assessed by using Interaction plots.
The geometric mean concentrations (detection rates) were 0.09 ng/mL (100.0%), 0.12 ng/mL (97.8%), 0.22 ng/mL (94.7%), 0.16 ng/mL (99.2%) and 0.28 ng/mL (100.0%) for PBDE-28, PBDE-47, PBDE-99, and PBDE-153 respectively. However, PBDE-28, PBDE-99, PBDE-100, and ΣPBDEs were positively associated with IFG (odds ratios (ORs) (95% confidence intervals (CIs)): 1.14 (1.06, 1.23), 1.16 (1.04, 1.29), 1.25 (1.14, 1.37), and 1.27 (1.08, 1.50)). Similarly, PBDE-28, PBDE-47, PBDE-99, PBDE-100, and ΣPBDEs were positively associated with T2DM (ORs (95% CIs): 1.30 (1.10, 1.54), 1.13 (1.06, 1.22), 1.27 (1.13, 1.43), 1.27 (1.15, 1.40), and 1.30 (1.10, 1.54)). Moreover, five PBDE mixtures or jointly as PBDE pollution score, were significantly associated with an increased risk of T2DM (P < 0.05 for all). In addition, the harmful effect of PBDE exposure on T2DM was decreased with accompanying high-density lipoprotein cholesterol (HDL-C) levels increased.
Our findings highlight the importance of managing PBDEs contamination and suggest that HDL-C may be a novel way to prevent T2DM.
血浆多溴二苯醚（PBDE）曾被广泛用作阻燃剂，然而，关于PBDE与2型糖尿病（T2DM）之间关联的流行病学证据并不一致。此外，在缺乏良好废物回收基础设施的农村地区，PBDE与血脂指标对空腹血糖受损（IFG）和T2DM的联合影响在很大程度上仍不清楚。
在本研究中，从河南农村队列中纳入了2607名年龄在18 - 79岁的受试者。应用广义线性和逻辑回归模型来评估各种PBDE污染物与IFG和T2DM之间的关联。采用分位数g计算回归和由自适应弹性网创建的PBDE污染评分来评估PBDE混合物对IFG和T2DM的影响。通过交互作用图评估个体PBDE污染物与血脂指标对IFG和T2DM的交互作用。
PBDE - 28、PBDE - 47、PBDE - 99和PBDE - 153的几何平均浓度（检出率）分别为0.09 ng/mL（100.0%）、0.12 ng/mL（97.8%）、0.22 ng/mL（94.7%）、0.16 ng/mL（99.2%）和0.28 ng/mL（100.0%）。然而，PBDE - 28、PBDE - 99、PBDE - 100和ΣPBDEs与IFG呈正相关（比值比（ORs）（95%置信区间（CIs））：1.14（1.06，1.23）、1.16（1.04，1.29）、1.25（1.14，1.37）和1.27（1.08，1.50））。同样，PBDE - 28、PBDE - 47、PBDE - 99、PBDE - 100和ΣPBDEs与T2DM呈正相关（ORs（95% CIs）：1.30（1.10，1.54）、1.13（1.06，1.22）、1.27（1.13，1.43）、1.27（1.15，1.40）和1.30（1.10，1.54））。此外，五种PBDE混合物或作为PBDE污染评分联合起来，与T2DM风险增加显著相关（所有P < 0.05）。此外，随着高密度脂蛋白胆固醇（HDL - C）水平升高，PBDE暴露对T2DM的有害影响降低。
我们的研究结果突出了管理PBDE污染的重要性，并表明HDL - C可能是预防T2DM的一种新方法。
