De Nguyen Van, Minh Pham Ngoc, Le Thanh Hoa, Dung Do Trung, Duong Tran Thanh, Tuan Bui Van, Dong Le Thanh, Vinh Chau Nguyen Van, Cuervo Pablo F, Bargues M Dolores, Valero M Adela, Gabrielli Albis Francesco, Montresor Antonio, Mas-Coma Santiago
Department of Parasitology, Ha Noi Medical University, Ha Noi, Vietnam.
Vietnam Academy of Science and Technology, Institute of Biotechnology, Ha Noi, Vietnam.
Open Forum Infect Dis. 2025 Mar 4;12(3):ofaf116. doi: 10.1093/ofid/ofaf116. eCollection 2025 Mar.
is the causal agent of human fascioliasis, which is emerging in southern Asia and increasingly reported in Africa. Unfortunately, knowledge of the clinical picture by is insufficient, because of the sporadic individual case reports, or few case series of short number of patients from areas where the 2 genetically pure fasciolid species geographically overlap and specific causality was not verified.
The clinical picture is assessed from patients examined in well-equipped hospitals of big cities in Vietnam. Records of 3250 -infected patients were registered in individual cards and a database for their complete analysis was constructed. Case profile was based on typical symptoms, blood eosinophilia, serological test, imaging techniques, Kato-Katz test, and ex juvantibus confirmation. Anamnesis furnished information about place of residence, professional activities, and infection source.
Symptoms, signs, and manifestations, including neurological, meningeal, neuropsychic, and ocular disorders, are analyzed according to frequency, sex, and age groups. Early patient diagnosis and treatment facilitated by radio broadcasting underlie differences between serological positivity, coprological positivity, and liver lesions and explain the absence of severe long-term complications and posttreatment sequelae.
This is the first sufficiently wide study of the clinical picture caused by . The assessment has been made in a population without previous contact with fascioliasis and shows that (and -like hybrids) do not cause clinical pictures different from those caused by This clinical picture will be useful for physicians and health officers in endemic areas of Asia and Africa.
[具体病原体名称]是人类肝片吸虫病的病原体，该病在亚洲南部呈上升趋势，在非洲的报告也日益增多。遗憾的是，由于零星的个案报告，或者来自两种基因纯合的肝片吸虫物种在地理上重叠且未证实特定因果关系地区的患者数量较少的少数病例系列，对[具体病原体名称]所致临床表现的了解并不充分。
对在越南大城市设备完善的医院接受检查的患者的临床表现进行评估。将3250例感染[具体病原体名称]患者的记录登记在个人卡片上，并建立数据库进行全面分析。病例概况基于典型症状、血液嗜酸性粒细胞增多、血清学检测、成像技术、加藤厚涂片法检测以及根据治疗效果进行确诊。病史提供了有关居住地点、职业活动和感染源的信息。
根据频率、性别和年龄组分析了包括神经、脑膜、神经精神和眼部疾病在内的症状、体征和表现。通过广播促进患者早期诊断和治疗是血清学阳性、粪便学阳性和肝脏病变之间差异的基础，并解释了为何没有严重的长期并发症和治疗后后遗症。
这是首次对[具体病原体名称]所致临床表现进行的足够广泛的研究。该评估是在未曾接触过肝片吸虫病的人群中进行的，结果表明[具体病原体名称]（以及类似[具体病原体名称]的杂交种）所致临床表现与[另一相关病原体名称]所致临床表现并无不同。这一临床表现将对亚洲和非洲流行地区的医生和卫生官员有用。
