Ma Yawei, Wang Zhongqing, Hu Yuedong
Department of Ophthalmology, The First Hospital of China Medical University, Shenyang, China.
Department of Information Center, The First Hospital of China Medical University, Shenyang, China.
Front Genet. 2023 Sep 15;14:1266680. doi: 10.3389/fgene.2023.1266680. eCollection 2023.
Nrf2 plays a pivotal role in governing the antioxidant defense system, triggering the transcription of diverse genes involved in cellular protection. Its role in mitigating oxidative damage and modulating inflammatory processes has made Nrf2 an attractive target for therapeutic interventions. Despite the growing interest in Nrf2 research, a bibliometric analysis is relatively rare. This study aimed to clarify Nrf2's role in multiple diseases, identify emerging trends and hotspots using bibliometric analysis, and provide valuable insights and potential directions for future therapeutic interventions. The Science Citation Index of Web of Science Core library from 2000 to 2022 was searched on 22 October 2022. Use Microsoft Excel, CiteSpace, Bibliometrix, and VOS viewers for data collection and visualization of research focus and trends. A vast collection of 22,040 research studies on Nrf2 published between 2000 and 2022 were identified. Nrf2 research has seen significant growth globally from 2000 to 2022. China leaded in publication numbers (9,623, 43.66%), while the United States dominated in citation frequency with 261,776 citations. China Medical University was the most productive institutions (459, 2.08%). Masayuki Yamamoto topped in publications (307), while Itoh K. ranked first in citations with 3669. Free Radical Biology and Medicine was the journal with the most studies and citations on Nrf2 (613, 29,687 citations). The analysis of keyword clustering enhanced the categorization of topics and can be summarized as oxidative stress, cancer, disorders in glycolipid metabolism, inflammation, and neurological conditions. China and the United States are the pioneers in Nrf2 research. Recently, there has been a comprehensive exploration of Nrf2 involving both experimental and clinical aspects, as well as mechanisms and therapeutic applications. Investigating novel molecular mechanisms, including NF-κB, Ho1, and Keap1, and developing enhanced, targeted Nrf2 activators or inhibitors to uncover the interplay among cancer, glycolipid metabolic disorder, inflammation, and neurological disorders will be upcoming trends and hotspots.
Nrf2在调控抗氧化防御系统中发挥着关键作用，可触发参与细胞保护的多种基因的转录。其在减轻氧化损伤和调节炎症过程中的作用，使Nrf2成为治疗干预的一个有吸引力的靶点。尽管对Nrf2研究的兴趣日益浓厚，但文献计量分析相对较少。本研究旨在阐明Nrf2在多种疾病中的作用，利用文献计量分析确定新出现的趋势和热点，并为未来的治疗干预提供有价值的见解和潜在方向。于2022年10月22日检索了Web of Science核心库2000年至2022年的科学引文索引。使用Microsoft Excel、CiteSpace、Bibliometrix和VOS viewer进行数据收集以及研究重点和趋势的可视化。共识别出2000年至2022年间发表的22040项关于Nrf2的研究。2000年至2022年期间，Nrf2研究在全球范围内有显著增长。中国在发表数量上领先（9623篇，占43.66%），而美国在被引频次上占主导地位，被引261776次。中国医科大学是产出最多的机构（459篇，占2.08%）。山本正之在发表文章数量上位居榜首（307篇），而伊藤公则以3669次的被引频次位居被引榜首。《自由基生物学与医学》是关于Nrf2研究和被引次数最多的期刊（613篇，被引29687次）。关键词聚类分析增强了主题分类，可概括为氧化应激、癌症、糖脂代谢紊乱、炎症和神经疾病。中国和美国是Nrf2研究的先驱。最近，对Nrf2进行了全面探索，涉及实验和临床方面以及机制和治疗应用。研究包括NF-κB、Ho1和Keap1在内的新分子机制，以及开发增强型、靶向性Nrf2激活剂或抑制剂，以揭示癌症、糖脂代谢紊乱、炎症和神经疾病之间的相互作用，将是未来的趋势和热点。
