Liu Jinren, Guo Changzhi, Li Chunxiang, Jia Qiushi, Xie Zhengrong, Wang Ziyue, Tian Hongda, Li Zhongyuan, Hao Liguo
Department of Molecular Imaging, School of Medical Technology, Qiqihar Medical University, Qiqihar, China.
Department of Molecular Imaging, The First Affiliated Hospital of Qiqihar Medical University, Qiqihar, China.
Front Chem. 2023 Sep 15;11:1249472. doi: 10.3389/fchem.2023.1249472. eCollection 2023.
The nano drug delivery system MnO/CDDP@PDA-Cy5.5 was synthesized in this study to increase the efficacy of Cisplatin (CDDP) on thyroid cancer and alleviate the damage to normal tissue, with the aim of enhancing the anti-cancer efficacy, increasing the drug load, optimizing the control of drug release, and alleviating the systemic toxicity arising from drug off-target. On that basis, high efficacy and low toxicity win-win can be obtained. In this study, hollow manganese dioxide nanoparticles (MnO NPs) were prepared based on the template method. CDDP was loaded into the hollow cavity and then modified with polydopamine (PDA) and Cy5.5, with the aim of obtaining the nano-drug loading system MnO/CDDP@PDA-Cy5.5 NPs. The NPs precisely delivered drugs by intelligently responding to the tumor microenvironment (TME). As indicated by the release curves, the NPs release CDDP rapidly by inducing the decomposition of PDA and MnO under acidic or redox conditions, and Magnetic resonance imaging (MRI) contrast agent Mn was generated. The results of the MRI studies suggested that T contrast at the tumor site was notably enhanced under the Enhanced permeability and retention (EPR) effect. After the intravenous administration, the effective tumor accumulation exhibited by the NPs was confirmed by magnetic resonance imaging as a function of time. Compared with free CDDP, the therapeutic effect was remarkably increased. As indicated by the above-described results, MnO/CDDP@PDA-Cy5.5 NPs is a drug delivery system exhibiting diagnostic and therapeutic functions.
本研究合成了纳米药物递送系统MnO/CDDP@PDA-Cy5.5，以提高顺铂（CDDP）对甲状腺癌的疗效并减轻对正常组织的损伤，旨在增强抗癌效果、增加药物负载量、优化药物释放控制并减轻药物脱靶引起的全身毒性。在此基础上，可实现高效低毒的双赢。本研究基于模板法制备了中空二氧化锰纳米颗粒（MnO NPs）。将CDDP载入中空腔内，然后用聚多巴胺（PDA）和Cy5.5进行修饰，旨在获得纳米载药系统MnO/CDDP@PDA-Cy5.5 NPs。这些纳米颗粒通过对肿瘤微环境（TME）的智能响应精确递送药物。如释放曲线所示，纳米颗粒在酸性或氧化还原条件下通过诱导PDA和MnO的分解快速释放CDDP，并生成磁共振成像（MRI）造影剂Mn。MRI研究结果表明，在增强的通透性和滞留（EPR）效应下，肿瘤部位的T造影明显增强。静脉给药后，通过磁共振成像证实了纳米颗粒随时间呈现出有效的肿瘤蓄积。与游离CDDP相比，治疗效果显著提高。上述结果表明，MnO/CDDP@PDA-Cy5.5 NPs是一种具有诊断和治疗功能的药物递送系统。
