College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, 100029, China.
Department of Chemistry, University of Toronto, Toronto, ON, M5S 3H6, Canada.
Nat Commun. 2023 Oct 2;14(1):6149. doi: 10.1038/s41467-023-41783-9.
Magnetic resonance (MR) angiography is one of the main diagnostic approaches for cardiac-cerebral vascular diseases. Nevertheless, the non-contrast-enhanced MR angiography suffers from its intrinsic problems derived from the blood flow-dependency, while the clinical Gd-chelating contrast agents are limited by their rapid vascular extravasation. Herein, we report a hypersensitive MR angiography strategy based on interlocking stratagem of zwitterionic Gd-chelate contrast agents (PAA-Gd). The longitudinal molar relaxivity of PAA-Gd was 4.6-times higher than that of individual Gd-chelates as well as appropriate blood half-life (73.8 min) and low immunogenicity, enabling sophisticated micro-vessels angiography with a resolution at the order of hundred micrometers. A series of animal models of cardiac-cerebrovascular diseases have been built for imaging studies on a 7.0 T MRI scanner, while the clinical translation potential of PAA-Gd has been evaluated on swine on a 3.0 T clinical MRI scanner. The current studies offer a promising strategy for precise diagnosis of vascular diseases.
磁共振血管造影术是心脑血管疾病的主要诊断方法之一。然而，非增强磁共振血管造影术受到其血流依赖性的固有问题的影响，而临床用的钆螯合物造影剂则受到其快速血管外渗的限制。在此，我们报告了一种基于两性离子 Gd 螯合物（PAA-Gd）连锁策略的高灵敏度磁共振血管造影术策略。PAA-Gd 的纵向摩尔弛豫率比单个 Gd 螯合物高 4.6 倍，且具有适当的血液半衰期（73.8 分钟）和低免疫原性，能够实现分辨率达到数百微米的精细微血管血管造影。我们已经建立了一系列心脑血管疾病的动物模型，用于在 7.0T MRI 扫描仪上进行成像研究，同时还在 3.0T 临床 MRI 扫描仪上对猪进行了 PAA-Gd 的临床转化潜力评估。目前的研究为血管疾病的精确诊断提供了一种有前景的策略。
