College of Materials Science and Engineering and College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.
Department of Psychiatry and Center for Preclinical Safety Evaluation of Drugs, West China Hospital of Sichuan University, Chengdu 610041, China.
Sci Adv. 2024 Oct 4;10(40):eadq4082. doi: 10.1126/sciadv.adq4082.
Magnetic resonance angiography (MRA) is pivotal for diagnosing panvascular diseases. However, single-modality MRA falls short in diagnosing diverse vascular abnormalities. Thus, contrast agents combining and effects are sought for multiparameter MRA with clinical promise, yet achieving a balance in and contrast enhancement effects remains a scientific challenge. Herein, we developed a hypersensitive multiparameter MRA strategy using dual-modality NaGdF nanoparticles. Because of the longer tumbling time (τ), NaGdF nanoparticles can improve the longitudinal relaxivity (), brightening vessels in -weighted sequences. Simultaneously, the regular arrangement of Gd in the crystal induces magnetic anisotropy, creating local static magnetic field heterogeneity and generating negative signals in -weighted sequences. Consequently, the efficacy of NaGdF-enhanced high-resolution multiparameter MRA has been validated in diagnosing ischemic stroke and Alzheimer's disease in rodent models. In addition, the dual-contrast imaging has been realized on swine with a clinical 3.0-T magnetic resonance imaging scanner, highly emphasizing the clinical translation prospect.
磁共振血管造影术（MRA）对诊断全血管疾病至关重要。然而，单模态 MRA 在诊断多种血管异常方面存在不足。因此，人们寻求具有临床应用前景的多参数 MRA 的 和 双重造影剂，但如何在 和 对比增强效果之间取得平衡仍是一个科学挑战。在此，我们使用双模态 NaGdF 纳米粒子开发了一种高灵敏度的多参数 MRA 策略。由于较长的旋转时间（τ），NaGdF 纳米粒子可以提高纵向弛豫率（），在 T1 加权序列中使血管变亮。同时，Gd 在晶体中的规则排列诱导磁各向异性，产生局部静态磁场不均匀性，并在 T2 加权序列中产生负信号。因此，NaGdF 增强高分辨率多参数 MRA 的功效已在啮齿动物模型中诊断缺血性中风和阿尔茨海默病方面得到验证。此外，在临床 3.0-T 磁共振成像扫描仪上对猪进行了双对比成像，高度强调了其临床转化前景。
