Biswas N M, Patra P B, Sanyal S, Deb C
Andrologia. 1979 May-Jun;11(3):227-33. doi: 10.1111/j.1439-0272.1979.tb02189.x.
Chronic nicotine administration in larger doses inhibits steroidogenesis in testis. This inhibition is possibly secondary to increased adrenomedullary norepinephrine activity, since the anti-steroidogenic effect of nicotine can be prevented by alpha-adrenergic blocker like phentolamine. In vitro incubation of testicular slices with nicotine failed to elicit any appreciable effect on delta 5-3 beta-hydroxysteroid dehydrogenase activity indicating lack of direct action of nicotine on testicular steroidogenesis.
大剂量长期给予尼古丁会抑制睾丸中的类固醇生成。这种抑制可能继发于肾上腺髓质去甲肾上腺素活性增加，因为尼古丁的抗类固醇生成作用可被酚妥拉明等α-肾上腺素能阻滞剂所阻断。睾丸切片与尼古丁进行体外孵育，未能对δ5-3β-羟基类固醇脱氢酶活性产生任何明显影响，这表明尼古丁对睾丸类固醇生成缺乏直接作用。
