Suppr超能文献

人乳头瘤病毒与前列腺癌:系统评价与荟萃分析。

Human papillomavirus and prostate cancer: systematic review and meta-analysis.

机构信息

Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, Tomsk, Russia, 634028.

National Research Tomsk State University, Tomsk, Russia, 634050.

出版信息

Sci Rep. 2023 Oct 3;13(1):16597. doi: 10.1038/s41598-023-43767-7.

Abstract

The involvement of human papillomavirus (HPV) in the prostate carcinogenesis is a controversial issue. The presented meta-analysis was carried out to systematize the currently available research results regarding this question. The meta-analysis includes case-control studies from 1991 to 2022, which were collected from publicly available bibliometric databases. The meta-analysis was performed using Meta-Essentials_1.5 software. We used Begg's and Egger's methods to assess publication bias. Cochran's Q test was used to assess heterogeneity and the I index was employed for calculating the variation in the pooled estimations. The analysis was based on data from 27 case-control studies, which in total yielded 1607 tumour tissue samples of prostate and 1515 control samples (317 samples of normal tissue, 1198 samples of benign prostatic hyperplasia (BPH)). According to the data obtained, there was high risk of prostate cancer by HPV infection in both cases. HPV was found in prostate cancer in 25.8% of cases, while in normal tissue samples the virus was detected in 9.2% of cases and in 17.4% with BPH as a control. In particular, more studies on the association of HPV and prostate cancer are needed to prove the role of HPV in the development of prostate cancer. In addition to the controversial question of whether HPV infection is associated with prostate cancer risk, it is worth considering whether the samples used as a control have an impact on the results. The impact of HPV in prostate tumour tissue samples on outcome should also be investigated.

摘要

人乳头瘤病毒(HPV)在前列腺癌发生中的作用是一个有争议的问题。本研究进行了荟萃分析,以系统地总结目前关于该问题的研究结果。荟萃分析包括 1991 年至 2022 年的病例对照研究,这些研究来自公开的文献计量数据库。荟萃分析使用 Meta-Essentials_1.5 软件进行。我们使用 Begg 和 Egger 法评估发表偏倚。Cochran's Q 检验用于评估异质性,I 指数用于计算汇总估计值的变异。该分析基于 27 项病例对照研究的数据,这些研究共获得 1607 份前列腺肿瘤组织样本和 1515 份对照样本(317 份正常组织样本,1198 份良性前列腺增生(BPH)样本)。根据获得的数据,HPV 感染导致前列腺癌的风险较高。HPV 在 25.8%的前列腺癌病例中被发现,而在正常组织样本中,病毒在 9.2%的病例中被发现,在作为对照的 BPH 中,病毒在 17.4%的病例中被发现。特别是,需要更多关于 HPV 与前列腺癌关联的研究来证明 HPV 在前列腺癌发展中的作用。除了 HPV 感染是否与前列腺癌风险相关的争议问题外,还值得考虑作为对照使用的样本是否会对结果产生影响。还应研究 HPV 在前列腺肿瘤组织样本中的作用对结果的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aada/10547781/71b7cb70743e/41598_2023_43767_Fig1_HTML.jpg

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验