Kumar Ritesh, Kumar Ujwal, Trivedi Sameer
Department of Endocrinology, Diabetes and Metabolism, Institute of Medical Sciences, Banaras Hindu University, Varanasi, IND.
Department of Urology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, IND.
Cureus. 2023 Sep 2;15(9):e44576. doi: 10.7759/cureus.44576. eCollection 2023 Sep.
We aim to compare the various risk factors for erectile dysfunction (ED) in type 2 diabetes mellitus (DM) and nondiabetic patients.
We retrospectively collected and evaluated the data of 175 OPD patients with ED. We included 138 patients of ED from endocrinology and urology OPD after exclusion. ED was assessed by using a questionnaire adapted from the abridged five-item version of the International Index of Erectile Function (IIEF-5) score.
A total of 96 (69.56%) were diabetic, and 42 (30.43%) were nondiabetic. The majority of patients (62.31 %) were in the age group of 40-60 years. Thirty-nine (28.26%) were alcoholics, and 55 (40%) were smokers. The average duration of diabetes was 6.6±1.5 years. Hypertension was present in 49 (35.5%). Diabetic patients were significantly older (47.9±8.2 vs. 40.2±7.6 years, p=0.0001) and obese (BMI (kg/m), 27.3±5.4 vs. 24.6±3.9, p=0.004). Waist circumference in diabetics was 95.3±10.9, as compared to nondiabetics, which was 89.6±9.2 cm (p=0.0037). The IIEF-5 score was significantly lower in diabetic subjects in comparison to nondiabetics (9.4±3.2 vs. 12.1±3.6 p=0.0001). Moderate-to-severe ED was more common in diabetic patients (76%) in comparison to nondiabetics (59.5%). The prevalence of mild and mild-to-moderate ED was 11.45 % and 12.5 % in diabetic patients in comparison to 16.7% and 23.5% in nondiabetics, respectively. The prevalence of hypertension and coronary artery was higher in diabetics in comparison with nondiabetics. Hypertension was significantly higher in diabetic patients with ED (42.7% vs. 19.04%, p=0.0075), but coronary artery disease was not statistically significant (8.3% vs. 2.3%, p=0.1925). LH (2.6±0.7 vs. 3.5±0, p=0.0001) and testosterone (312.1±110.7 vs. 367.8±115.1, p=0.0081) were significantly lower in diabetics in comparison to nondiabetics.
The IIEF-5 score was lower in diabetic cases as compared to those without diabetes. The factors that significantly contributed to ED in type 2 DM patients, as compared to nondiabetic patients, were age, BMI, waist circumference, hypertension, poor glycemic control, LH, and testosterone levels.
我们旨在比较2型糖尿病（DM）患者和非糖尿病患者勃起功能障碍（ED）的各种危险因素。
我们回顾性收集并评估了175例门诊ED患者的数据。排除后，我们纳入了来自内分泌科和泌尿外科门诊的138例ED患者。采用改编自国际勃起功能指数简版五项问卷（IIEF-5）评分来评估ED。
共有96例（69.56%）为糖尿病患者，42例（30.43%）为非糖尿病患者。大多数患者（62.31%）年龄在40 - 60岁之间。39例（28.26%）为酗酒者，55例（40%）为吸烟者。糖尿病平均病程为6.6±1.5年。49例（35.5%）患有高血压。糖尿病患者年龄显著更大（47.9±8.2岁 vs. 40.2±7.6岁，p = 0.0001）且更肥胖（BMI（kg/m），27.3±5.4 vs. 24.6±3.9，p = 0.004）。糖尿病患者的腰围为95.3±10.9，而非糖尿病患者为89.6±9.2 cm（p = 0.0037）。与非糖尿病患者相比，糖尿病患者的IIEF-5评分显著更低（9.4±3.2 vs. 12.1±3.6，p = 0.0001）。与非糖尿病患者（59.5%）相比，中重度ED在糖尿病患者中更常见（76%）。糖尿病患者轻度和轻度至中度ED的患病率分别为11.45%和12.5%，而非糖尿病患者分别为16.7%和23.5%。与非糖尿病患者相比，糖尿病患者高血压和冠状动脉疾病的患病率更高。ED糖尿病患者的高血压患病率显著更高（42.7% vs. 19.04%，p = 0.0075），但冠状动脉疾病无统计学意义（8.3% vs. 2.3%，p = 0.1925）。与非糖尿病患者相比，糖尿病患者的促黄体生成素（LH）（2.6±0.7 vs. 3.5±0，p = 0.0001）和睾酮（312.1±110.7 vs. 367.8±115.1，p = 0.0081）显著更低。
与无糖尿病患者相比，糖尿病患者的IIEF-5评分更低。与非糖尿病患者相比，2型糖尿病患者中对ED有显著影响的因素包括年龄、BMI、腰围、高血压、血糖控制不佳、LH和睾酮水平。
