2型糖尿病且无明显心血管疾病个体的勃起功能障碍与心血管风险之间的关联
Association between erectile dysfunction and cardiovascular risk in individuals with type-2 diabetes without overt cardiovascular disease.
作者信息
Meena Babu Lal, Kochar Dhanpat Kumar, Agarwal Tulsi Das, Choudhary Raghvendra, Kochar Abhishek
机构信息
Department of Medicine, S.P. Medical College, Bikaner, Rajasthan, India.
出版信息
Int J Diabetes Dev Ctries. 2009 Oct;29(4):150-4. doi: 10.4103/0973-3930.57345.
BACKGROUND
Erectile dysfunction in type-2 diabetes may be an independent marker for coronary artery disease. Present study was undertaken to investigate whether type-2 diabetic patients with erectile dysfunction without having overt cardiovascular disease had increased cardiovascular risk.
AIM
To find out correlation between ED and cardiovascular risk in diabetic patients.
METHODS
Fifty type-2 diabetic patients were assessed for erectile dysfunction using international index of erectile dysfunction (IIEF-5), which include questionnaire and cardiovascular risk assessment by multiparameter cardiovascular analysis device (periscope).
RESULTS
The prevalence of erectile dysfunction in type-2 diabetics was very high (78%), mild, moderate and severe ED was present in 6, 36 and 36%, respectively. The total cardiovascular risk was more in patients with ED in comparison to patients without ED (34.87 +/- 18.82 vs 20.91 +/- 11.03 p = 0.002). The mean 10-years coronary risk and cardiac risk was 12.00 + 9.60 and 22.23 + 14.14 (p = 0.029) and 13.36 +/- 1.22 and 28.85 +/- 4.13 (p 0.002) in patients without ED and with ED respectively. The mean vascular and atherosclerosis risk was 28.73 +/- 13.94 and 39.38 +/- 19.51 (p > 0.05) and 26.18 +/- 10.31 and 33.92 +/- 13.40 (p > 0.05) in patients without ED and with ED, respectively. Total cardiovascular risk was found to increase with age, duration of diabetes and HbA1c levels.
CONCLUSION
The total cardiovascular risk increases with increasing severity of erectile dysfunction in type-2 diabetic patients without having overt cardiovascular disease.
背景
2型糖尿病患者的勃起功能障碍可能是冠状动脉疾病的一个独立标志物。本研究旨在调查无明显心血管疾病的2型糖尿病勃起功能障碍患者的心血管风险是否增加。
目的
找出糖尿病患者勃起功能障碍与心血管风险之间的相关性。
方法
使用国际勃起功能指数（IIEF-5）对50例2型糖尿病患者进行勃起功能障碍评估，该指数包括问卷调查，并通过多参数心血管分析设备（潜望镜）进行心血管风险评估。
结果
2型糖尿病患者勃起功能障碍的患病率非常高（78%），轻度、中度和重度勃起功能障碍分别占6%、36%和36%。与无勃起功能障碍的患者相比，有勃起功能障碍的患者总心血管风险更高（34.87±18.82对20.91±11.03，p=0.002）。无勃起功能障碍和有勃起功能障碍的患者的平均10年冠心病风险和心脏风险分别为12.00+9.60和22.23+14.14（p=0.029）以及13.36±1.22和28.85±4.13（p=0.002）。无勃起功能障碍和有勃起功能障碍的患者的平均血管和动脉粥样硬化风险分别为28.73±13.94和39.38±19.51（p>0.05）以及26.18±10.31和33.92±13.40（p>0.05）。总心血管风险随年龄、糖尿病病程和糖化血红蛋白水平的增加而增加。
结论
在无明显心血管疾病的2型糖尿病患者中，总心血管风险随着勃起功能障碍严重程度的增加而增加。
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