Emet Abdulsamet, Demirtas Yunus, Beydemir Ataberk, Ayvaz Mehmet
Orthopedics and Traumatology, Etlik City Hospital, Ankara, TUR.
Orthopedics and Traumatology, Yuksek Ihtisas University Medical School, Ankara, TUR.
Cureus. 2023 Sep 30;15(9):e46270. doi: 10.7759/cureus.46270. eCollection 2023 Sep.
Extremity-sparing surgery should be the main objective if a functional extremity is to be obtained in cases of malignant bone tumors. After extensive resection, numerous techniques have been described to reconstruct bone defects. This study aimed to compare the outcomes of patients who underwent external radiation therapy and liquid nitrogen biological reconstruction at two different facilities.
The study included 12 patients who received biological reconstruction therapy for bone sarcoma and had at least two years of follow-up. Demographic data, pathological diagnosis, presence of systemic metastasis, and recurrence during follow-up were among the information logged. Patients who used liquid nitrogen were placed in group 1, and those who underwent external irradiation were placed in group 2. After being contacted for their final follow-up appointments, the outcomes were compared by recording the Musculoskeletal Tumor Society Score (MSTSS).
For participants with a mean age of 10.75±3.6 (5-17), the follow-up period was 30.2±16.3 months in total. In contrast to the patients in group 1, who experienced union on average after 7.5±1.2 months, those in group 2 experienced union after 7.6±1.1 months. Patients in group 1 had an MSTSS of 75.5±11.8%, while those in group 2 had a score of 77±4.4. There was no discernible difference between the two groups' union times (p>0.05). There was no statistically significant difference between the two groups' MSTSS (p>0.05).
After tumor resection, extracorporeal radiation therapy and the application of liquid nitrogen are still useful treatment options and neither of them is superior to the other.
如果要在恶性骨肿瘤病例中获得功能正常的肢体，保肢手术应是主要目标。在广泛切除后，已有多种技术被描述用于重建骨缺损。本研究旨在比较在两个不同机构接受外照射放疗和液氮生物重建的患者的治疗结果。
该研究纳入了12例接受骨肉瘤生物重建治疗且至少随访两年的患者。记录的信息包括人口统计学数据、病理诊断、全身转移情况以及随访期间的复发情况。使用液氮的患者被归入第1组，接受外照射放疗的患者被归入第2组。在联系他们进行最后一次随访预约后，通过记录肌肉骨骼肿瘤学会评分（MSTSS）来比较治疗结果。
对于平均年龄为10.75±3.6岁（5 - 17岁）的参与者，总随访期为30.2±16.3个月。与第1组平均在7.5±1.2个月后实现骨愈合的患者相比，第2组患者在7.6±1.1个月后实现骨愈合。第1组患者的MSTSS为75.5±11.8%，而第2组患者的评分为77±4.4。两组的骨愈合时间之间没有明显差异（p>0.05）。两组的MSTSS之间也没有统计学上的显著差异（p>0.0）。
肿瘤切除后，体外放疗和液氮应用仍然是有用的治疗选择，且两者并无优劣之分。
