Tissue Bank, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Graduate Institute of Health Industry Technology, Research Center for Food and Cosmetic Safety, Research Center for Chinese Herbal Medicine, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, Taiwan.
Nat Commun. 2022 Mar 9;13(1):1238. doi: 10.1038/s41467-022-28908-2.
In the long history of traditional Chinese medicine, single herbs and complex formulas have been suggested to increase lifespan. However, the identification of single molecules responsible for lifespan extension has been challenging. Here, we collected a list of traditional Chinese medicines with potential longevity properties from pharmacopeias. By utilizing the mother enrichment program, we systematically screened these traditional Chinese medicines and identified a single herb, Psoralea corylifolia, that increases lifespan in Saccharomyces cerevisiae. Next, twenty-two pure compounds were isolated from Psoralea corylifolia. One of the compounds, corylin, was found to extend the replicative lifespan in yeast by targeting the Gtr1 protein. In human umbilical vein endothelial cells, RNA sequencing data showed that corylin ameliorates cellular senescence. We also examined an in vivo mammalian model, and found that corylin extends lifespan in mice fed a high-fat diet. Taken together, these findings suggest that corylin may promote longevity.
在中医药的悠久历史中，单味草药和复方方剂都被认为可以延长寿命。然而，鉴定出延长寿命的单一分子一直具有挑战性。在这里，我们从药典中收集了具有潜在长寿特性的一系列传统中药。通过利用母液富集程序，我们系统地筛选了这些传统中药，并鉴定出一种单味草药，补骨脂，它可以延长酿酒酵母的寿命。接下来，从补骨脂中分离出 22 种纯化合物。其中一种化合物，补骨脂素，通过靶向 Gtr1 蛋白，延长了酵母的复制寿命。在人脐静脉内皮细胞中，RNA 测序数据表明，补骨脂素可以改善细胞衰老。我们还检查了一个体内哺乳动物模型，发现补骨脂素可以延长高脂肪饮食喂养的小鼠的寿命。总之，这些发现表明补骨脂素可能具有促进长寿的作用。
