Quinlivan Esther, Renneberg Babette, Schreiter Stefanie, Friedel Eva, Shmuilovich Olga, Stamm Thomas
Department of Psychiatry and Neurosciences, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Clinical Psychology and Psychotherapy, Freie Universität Berlin, Berlin, Germany.
Front Psychiatry. 2023 Sep 18;14:1258303. doi: 10.3389/fpsyt.2023.1258303. eCollection 2023.
Studies comparing objective and self-reported cognitive functioning as well as influencing factors in individuals with remitted bipolar disorder are scarce and contradictory.
The aim of this study was to compare executive functioning and other objective and self-reported cognitive impairment between 26 individuals with remitted bipolar disorder (15 BD I) and 24 healthy controls using a cross-sectional design. Executive functions were measured by the TAP Go/No-go subtest as well as the Stroop Task. Self-rated functioning was assessed using the Attention Deficit Experience Questionnaire. In addition, possible predictors of self-reported and objective cognitive functioning were examined to perform regression analyses.
Individuals with remitted bipolar disorder did not differ significantly in executive functions or other objective cognitive domains from the healthy control group, but showed a significantly lower level of self-reported cognitive functioning and self-esteem. While self-esteem was the strongest predictor in healthy controls for self-reported cognitive functioning, severity of illness and subthreshold depressive mood were the most important predictors in individuals with remitted bipolar disorder.
The results once again demonstrate the cognitive heterogeneity in bipolar disorder. In the treatment of cognitive deficits, factors such as subthreshold depressive symptomatology and self-esteem should be focused on in addition to cognitive training in remitted patients.
比较缓解期双相情感障碍患者客观和自我报告的认知功能以及影响因素的研究较少且结果相互矛盾。
本研究旨在采用横断面设计,比较26例缓解期双相情感障碍患者(15例双相I型)和24名健康对照者的执行功能以及其他客观和自我报告的认知障碍。执行功能通过TAP Go/No-go子测验以及Stroop任务进行测量。使用注意力缺陷体验问卷评估自我评定功能。此外,对自我报告和客观认知功能的可能预测因素进行检查以进行回归分析。
缓解期双相情感障碍患者在执行功能或其他客观认知领域与健康对照组无显著差异,但自我报告的认知功能和自尊水平显著较低。虽然自尊是健康对照组自我报告认知功能的最强预测因素,但疾病严重程度和阈下抑郁情绪是缓解期双相情感障碍患者最重要的预测因素。
结果再次证明双相情感障碍存在认知异质性。在治疗认知缺陷时,除了对缓解期患者进行认知训练外,还应关注阈下抑郁症状和自尊等因素。