Richard F, Renard L, Wambersie A
Bull Cancer. 1986;73(5):562-8.
From March 1978 to August 1985, 630 patients were treated with fast neutrons at the UCL cyclotron of Louvain-la-Neuve. Neutrons are produced by bombarding a beryllium target with 65 MeV protons. A CNPF of 2.8 was adopted. As far as soft tissue sarcomas are concerned, 32 patients were irradiated after "radical" surgery: only 2 local recurrences were observed (follow-up from 6 months to more that 5 years). On the other hand, in a group of 26 patients with large inoperable, recurrent of incompletely resected tumours, local control could not be achieved in 14 cases. In the whole group of these 58 patients, 12 severe complications were observed; their frequency increases with field size which in turn reflects tumour extent. Locally extended prostatic adenocarcinomas (stage C) were treated with mixed schedule irradiation (3 neutron and 2 photon fractions per week). A local control rate of 93% at 1 year, of 83% at 2 years, and 90% at 3 years was achieved (28, 23 and 10 patients respectively). The early and late tolerance was excellent; only one complication was observed.
1978年3月至1985年8月期间，630名患者在鲁汶新堡的鲁汶大学回旋加速器接受快中子治疗。中子是通过用65兆电子伏特的质子轰击铍靶产生的。采用了2.8的CNPF。就软组织肉瘤而言，32名患者在“根治性”手术后接受了放疗：仅观察到2例局部复发（随访时间从6个月至5年以上）。另一方面，在一组26例无法手术、复发或未完全切除肿瘤的患者中，14例未能实现局部控制。在这58例患者的整个组中，观察到12例严重并发症；其发生率随照射野大小增加，而照射野大小又反映肿瘤范围。局部扩展的前列腺腺癌（C期）采用混合方案放疗（每周3次中子和2次光子分割照射）。1年、2年和3年的局部控制率分别为93%、83%和90%（分别为28例、23例和10例患者）。早期和晚期耐受性良好；仅观察到1例并发症。
