Crammer J L
Br J Psychiatry. 1986 Sep;149:337-45. doi: 10.1192/bjp.149.3.337.
Specific questioning and frequent observation of a 69 year-old woman with cyclic bipolar manic-depressive illness showed that she had disturbances of thirst, appetite, bowel and bladder function and dramatic changes in body weight, in association with different phases of her mental illness. Examination of one manic phase under constant diet and inpatient control showed cardiovascular changes, sodium retention, body weight gain, with raised aldosterone secretion but steady vasopressin. There appears to be a sub-group of manic-depressive patients with evidence of disturbed hypothalamic functions as part of their mental illness, as shown particularly by changes in water and electrolyte metabolism.
对一名患有周期性双相躁狂抑郁症的69岁女性进行的详细询问和频繁观察显示，在其精神疾病的不同阶段，她出现了口渴、食欲、肠道和膀胱功能紊乱以及体重的显著变化。在持续饮食和住院控制下对一个躁狂期进行检查发现，存在心血管变化、钠潴留、体重增加，同时醛固酮分泌增加但抗利尿激素稳定。似乎有一部分躁狂抑郁症患者存在下丘脑功能紊乱的迹象，这是其精神疾病的一部分，尤其表现为水和电解质代谢的变化。
