Saran B M, Russell G F
Psychol Med. 1976 Aug;6(3):381-92. doi: 10.1017/s0033291700015816.
Eleven patients in remission from manic-depressive illness were studied by means of metabolic balances before and after the administration of lithium carbonate. Lithium caused a sharp diuresis of isotonic saline and a smaller excretion of potassium over the course of two days. During the subsequent two days there occurred a compensatory retention of Na, K and water. These short-term changes were not associated with any significant alteration in the patients' mood. There was no significant and systematic retention of Na, K or water over the 14 days of Li administration. The recovery of Li was measured simultaneously. During the first week only a proportion of the administered Li was recovered in the urine and faeces, suggesting that a gradual distribution of Li throughout its body space was occurring. After the first week, nearly all the administered Li was recovered, indicating an equilibrium with an even distribution of the ion throughout its body space. This equilibrium was more complete at this early stage in those patients who had been given a smaller dose of lithium carbonate.
对11名躁郁症缓解期患者在服用碳酸锂前后进行了代谢平衡研究。在两天时间里，锂导致等渗盐水大量利尿，钾排泄量减少。在随后的两天里，出现了钠、钾和水的代偿性潴留。这些短期变化与患者情绪的任何显著改变均无关联。在服用锂的14天内，钠、钾或水没有显著且系统性的潴留。同时测定了锂的回收率。在第一周，仅一部分服用的锂在尿液和粪便中回收，这表明锂在其全身空间中逐渐分布。第一周后，几乎所有服用的锂都被回收，这表明离子在其全身空间中均匀分布并达到平衡。在早期阶段，服用较小剂量碳酸锂的患者中这种平衡更为完全。
