Wen Xiangfu, Cheng Jia, Liu Mingchao
College of Veterinary Medicine, Hebei Agricultural University, Bao Ding, China.
Key Laboratory of Healthy Breeding in Dairy Cattle (Co-construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Hebei Agricultural University, Baoding, China.
Virulence. 2025 Dec;16(1):2467161. doi: 10.1080/21505594.2025.2467161. Epub 2025 Feb 21.
is a prevalent opportunistic pathogen responsible for a wide range of infections in livestock and wildlife, such as in cattle, pigs, European bison and forest musk deer. Much of the successful infection of relies on its virulence factors, including pyolysin as well as adhesion factors. The swift rise of bacterial resistance has highlighted the urgent need for developing new therapeutic strategies. Currently, virulence factor-mediated vaccine development and other therapeutic approaches are widely regarded as the primary interventions for addressing diseases associated with this pathogen. This review examines the broader virulence potential of , focusing on haemolysin, host cell adhesion proteins, the prevalence of antibiotic resistance, and the development of vaccines mediated by virulence factors. Additionally, it discusses current and future approaches aimed at improving therapeutic interventions.
是一种常见的机会致病菌,可导致家畜和野生动物发生多种感染,如牛、猪、欧洲野牛和林麝。 的许多成功感染都依赖于其毒力因子,包括溶血素以及黏附因子。细菌耐药性的迅速上升凸显了开发新治疗策略的迫切需求。目前,毒力因子介导的疫苗开发和其他治疗方法被广泛认为是应对与该病原体相关疾病的主要干预措施。本综述研究了 的更广泛毒力潜力,重点关注溶血素、宿主细胞黏附蛋白、抗生素耐药性的流行情况以及毒力因子介导的疫苗开发。此外,还讨论了旨在改善治疗干预措施的当前和未来方法。