Department of Biological Sciences, University of Notre Dame, Notre Dame, USA.
Tissue Barriers. 2024 Jul 2;12(3):2257110. doi: 10.1080/21688370.2023.2257110. Epub 2023 Oct 4.
The rising prevalence of fungal infections is a significant and growing public health threat, and this risk is further underscored by our incomplete understanding of why organs like the kidney are so susceptible to systemic candidiasis. To combat the high mortality of such infections, we urgently need to advance our understanding of fungal pathogenesis and how it articulates with human immune response. Now, a recent landmark study has illuminated a crucial role of the complement system in the response to candidiasis and determined the stepwise local response of phagocytes within the kidney during infection. These fundamental discoveries provide crucial insights that can be leveraged to improve the care and outcome for patients with fungal infections.
真菌性感染的发病率不断上升，对公众健康构成了重大且日益严重的威胁。此外，我们对肾脏等器官为何如此容易受到系统性念珠菌病影响的原因也缺乏了解，这进一步加剧了这种风险。为了应对此类感染的高死亡率，我们迫切需要深入了解真菌病的发病机制，以及它与人体免疫反应的相互作用。现在，最近一项具有里程碑意义的研究阐明了补体系统在对抗念珠菌病中的关键作用，并确定了感染过程中肾脏中吞噬细胞的逐步局部反应。这些基础性发现提供了至关重要的见解，可用于改善真菌感染患者的护理和预后。
