Wang Je-Chuang, Huang Wen-Chien, Cheng Ken-Fa, Liu Nien-Tung, Wu Kuo-Hui
Department of Chemistry and Materials Engineering, Chung Cheng Institute of Technology, National Defense University Tahsi Taoyuan 33551 Taiwan
RSC Adv. 2023 Oct 3;13(41):28904-28911. doi: 10.1039/d3ra04965e. eCollection 2023 Sep 26.
In this study, we evaluated the deactivating efficacy of strong basicity-based (T4-102) and hydrogen peroxide-based (DF-200) disinfectants that were past their expiration date when used to deactivate biological and chemical toxins on building material surfaces. The decontamination efficacies of DF-200 and T4-102 disinfectants against dimethyl methylphosphonate (DMMP) and 2-chloroethyl ethylsulfide (2-CEES) were studied using GC-MS analysis. The bactericidal efficacies of disinfectants against Gram-negative and , and Gram-positive and , were assessed in terms of the zone of inhibition, minimum inhibitory concentration (MIC), and minimum bactericidal concentration (MBC). The results indicated that the deactivation efficacy varied significantly according to the disinfectant amount, contact time, and building material. Higher efficacy of up to 99-100% was observed for biological toxins, despite passing their expiration dates. Approximately 70-78% of deactivation efficacies were observed for disinfectants against DMMP on the tile coupon at 100 μL and 24 h contact time. Moreover, the deactivation efficacy of DF-200 was better than that of T4-102. The data presented here demonstrate that the responders may use past-expiration-date disinfectants for efficacious disinfectaion in large-scale contamination incidents.
在本研究中，我们评估了过期的强碱性消毒剂（T4 - 102）和过氧化氢基消毒剂（DF - 200）用于灭活建筑材料表面生物和化学毒素的效果。使用气相色谱 - 质谱联用（GC - MS）分析研究了DF - 200和T4 - 102消毒剂对甲基膦酸二甲酯（DMMP）和2 - 氯乙基乙硫醚（2 - CEES）的去污效果。根据抑菌圈、最低抑菌浓度（MIC）和最低杀菌浓度（MBC）评估了消毒剂对革兰氏阴性菌和革兰氏阳性菌的杀菌效果。结果表明，灭活效果因消毒剂量、接触时间和建筑材料的不同而有显著差异。尽管已过保质期，但对生物毒素仍观察到高达99 - 100%的较高灭活效果。在瓷砖试片上，100 μL且接触时间为24小时时，消毒剂对DMMP的灭活效果约为70 - 78%。此外，DF - 200的灭活效果优于T4 - 102。此处呈现的数据表明，在大规模污染事件中，响应者可使用过期消毒剂进行有效消毒。
