Patz Caroline, Liviskie Caren, Bird Merielle, Zeller Brandy, Vesoulis Zachary A, Smyser Christopher D, McPherson Christopher
Department of Pharmacy (CP, CL, BZ, CM), St. Louis Children's Hospital, St. Louis, MO.
Department of Neurology (MB, CDS), Washington University School of Medicine, St. Louis, MO.
J Pediatr Pharmacol Ther. 2023;28(4):368-373. doi: 10.5863/1551-6776-28.4.368. Epub 2023 Aug 9.
We describe a single center experience with gabapentin as adjunctive therapy in infants with neonatal opioid withdrawal syndrome (NOWS).
We performed a retrospective chart review of infants receiving gabapentin for NOWS. Data points collected included patient's sex, gestational age, maternal opioid exposure, NOWS medication dosing and length of therapy, number of failed wean attempts, time to successful morphine wean and duration of morphine wean, length of stay in the neonatal intensive care unit (NICU), and NOWS medications at discharge.
Six infants received gabapentin as adjunctive treatment for NOWS. All infants failed 2-4 morphine weans before initiation of gabapentin despite the addition of clonidine. All infants that received gabapentin were successfully weaned off morphine. The time to wean off morphine after gabapentin initiation varied from 4-35 days. Maximum gabapentin doses ranged from 15 - 42.7 mg/kg/day. Five infants were discharged from the NICU on gabapentin.
Gabapentin appeared to facilitate successful morphine weans in six patients with NOWS who were previously unable to wean despite the initiation of clonidine.
我们描述了在新生儿阿片类药物戒断综合征（NOWS）婴儿中使用加巴喷丁作为辅助治疗的单中心经验。
我们对接受加巴喷丁治疗NOWS的婴儿进行了回顾性病历审查。收集的数据点包括患者的性别、胎龄、母亲阿片类药物暴露情况、NOWS药物剂量和治疗时长、断奶尝试失败次数、成功停用吗啡的时间和吗啡断奶持续时间、新生儿重症监护病房（NICU）住院时长以及出院时的NOWS药物。
六名婴儿接受加巴喷丁作为NOWS的辅助治疗。尽管加用了可乐定，但所有婴儿在开始使用加巴喷丁之前有2 - 4次吗啡断奶失败。所有接受加巴喷丁治疗的婴儿均成功停用吗啡。开始使用加巴喷丁后停用吗啡的时间为4 - 35天不等。加巴喷丁最大剂量范围为15 - 42.7毫克/千克/天。五名婴儿在NICU出院时仍使用加巴喷丁。
加巴喷丁似乎有助于六名NOWS患者成功停用吗啡，这些患者此前尽管开始使用了可乐定但仍无法断奶。
