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埃米尔·海茨与异染色质概念:染色体纵向分化在五十年前就已被认识到。

Emil Heitz and the concept of heterochromatin: longitudinal chromosome differentiation was recognized fifty years ago.

作者信息

Passarge E

出版信息

Am J Hum Genet. 1979 Mar;31(2):106-15.

PMID:377956
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1685768/
Abstract

The work of Emil Heitz (1892--1965) laid one of the keystones of cytogenetics. Using a new in situ method, he established between 1928 and 1935 the longitudinal differentiation of chromosomes in euchromatin (genetically active) and heterochromatin (genetically inert). He recognized the association of satellited chromosomes with the formation of the nucleolus, co-discovered the giant salivary chromosomes of diptera, and arrived at a cytological and genetic concept of chromosome structure that has been found essentially correct to date. Yet, Emil Heitz did not gain due recognition by his contemporaries, suffered from the political disturbances of his time, and spent almost a lifetime in isolation, bolstered only by the conviction that his scientific work was significant.

摘要

埃米尔·海茨(1892 - 1965)的工作为细胞遗传学奠定了基石之一。他采用一种新的原位方法,在1928年至1935年间确定了常染色质(基因活跃)和异染色质(基因惰性)中染色体的纵向分化。他认识到带有随体的染色体与核仁形成的关联,共同发现了双翅目昆虫的巨大唾液腺染色体,并得出了一种至今仍被认为基本正确的染色体结构的细胞学和遗传学概念。然而,埃米尔·海茨并未得到同时代人的应有认可,遭受了他那个时代政治动荡的影响,几乎一生都处于孤立状态,仅靠坚信自己的科学工作具有重要意义来支撑。

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本文引用的文献

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A NEW METHOD FOR THE STUDY OF CHROMOSOME REARRANGEMENTS AND THE PLOTTING OF CHROMOSOME MAPS.一种研究染色体重排及绘制染色体图谱的新方法。
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Inert Regions of Chromosomes as the Temporary Products of Individual Genes.染色体的惰性区域作为单个基因的临时产物
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The Individual Gene in Relation to the Chromomere and the Chromosome.与染色粒和染色体相关的单个基因。
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Micro-RNAs in breast cancer progression and metastasis: A chromatin and metabolic perspective.从染色质和代谢角度看微小RNA在乳腺癌进展和转移中的作用
Heliyon. 2024 Sep 20;10(19):e38193. doi: 10.1016/j.heliyon.2024.e38193. eCollection 2024 Oct 15.
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Nucleolus and centromere Tyramide Signal Amplification-Seq reveals variable localization of heterochromatin in different cell types.核仁与着丝粒 Tyramide 信号放大测序揭示了不同细胞类型中异染色质的位置可变性。
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DNA double-strand break movement in heterochromatin depends on the histone acetyltransferase dGcn5.异染色质中 DNA 双链断裂的移动依赖于组蛋白乙酰转移酶 dGcn5。
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Regulation of heterochromatin organization in plants.植物异染色质组织的调控。
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10
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Proc Natl Acad Sci U S A. 1935 Jan;21(1):16-26. doi: 10.1073/pnas.21.1.16.
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Heterochromatin in mammals.哺乳动物中的异染色质。
Arch Julius Klaus Stift Vererbungsforsch Sozialanthropol Rassenhyg. 1967;42(1-2):1-60.
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Chromosomal localization of mouse satellite DNA.小鼠卫星DNA的染色体定位
Science. 1970 Jun 12;168(3937):1356-8. doi: 10.1126/science.168.3937.1356.
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Heterochromatin.异染色质
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The structure and function of chromatin.染色质的结构与功能。
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Localization of heterochromatin in human chromosomes.人类染色体中异染色质的定位
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