Mikou Panagiota, Pergaris Alexandros, Engels Marianne, Chandra Ashish
Laiko Hospital, Athens, Greece.
First Department of Pathology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Cytopathology. 2024 Jan;35(1):16-22. doi: 10.1111/cyt.13313. Epub 2023 Oct 5.
The International System for Reporting Serous Fluid Cytology (TIS) has been proposed by an expert working team composed of the International Academy of Cytology and the American Society of Cytopathology, following an international survey. Since its introduction, the TIS has gained worldwide acceptance, and this review aims to assess its global impact. A literature search revealed 25 studies which have presented data on the impact of the TIS. Most of them provide data, including risk of malignancy (ROM) for each diagnostic category, separately for pleural, peritoneal and pericardial effusions, while a few do not separate them. A few studies focus on specific diagnoses like mesothelioma on specific types of fluids or more specific issues like the optimal fluid volume for cytology or interobserver variability. A synopsis of the data from the literature search is presented in four tables. The ROM assessment is discussed, as well as interobserver variability and the use of ancillary diagnostic immunochemistry. In conclusion, our review of the published data suggests that the TIS is a valid classification scheme that has been widely accepted by pathologists globally, is highly reproducible and makes a valuable contribution to clinical therapeutic management.
国际浆液性液体细胞学报告系统（TIS）由国际细胞学会和美国细胞病理学会组成的专家工作团队在一项国际调查后提出。自推出以来，TIS已获得全球认可，本综述旨在评估其全球影响。文献检索发现了25项呈现TIS影响数据的研究。其中大多数提供了数据，包括每个诊断类别的恶性风险（ROM），分别针对胸腔积液、腹腔积液和心包积液，而少数研究未对其进行区分。一些研究专注于特定诊断，如特定类型液体中的间皮瘤，或更具体的问题，如细胞学检查的最佳液体量或观察者间的变异性。文献检索数据的概要列于四个表格中。讨论了ROM评估、观察者间变异性以及辅助诊断免疫化学的应用。总之，我们对已发表数据的综述表明，TIS是一种有效的分类方案，已被全球病理学家广泛接受，具有高度可重复性，并对临床治疗管理做出了宝贵贡献。
