Christofidis Konstantinos, Theochari Maria, Mavropoulos Papoudas Stylianos, Kiohou Lamprini, Sousouris Stylianos, Dimitriadou Areti, Volakakis Nikolaos, Maounis Nicoletta, Mikou Panagiota
Cytopathology Laboratory, "Laiko" General Hospital of Athens, 11527 Athens, Greece.
Oncology Unit, "Hippokration" General Hospital of Athens, 11527 Athens, Greece.
Biomedicines. 2024 Apr 18;12(4):899. doi: 10.3390/biomedicines12040899.
This study aimed to investigate the optimal volume of serous fluid needed for accurate diagnosis using The International System for Reporting Serous Fluid Cytopathology (TIS), as well as to provide information on the distribution of serous effusion cases in the TIS categories (ND: non-diagnostic, NFM: negative for malignancy, AUS: atypia of undetermined significance, SFM: suspicious for malignancy, MAL: malignant) and relevant epidemiological data.
A retrospective analysis of 2340 serous effusion cases (pleural, peritoneal, and pericardial) from two hospitals between 2018 and 2020 was conducted. TIS categories were assigned to each case, and for 1181 cases, these were correlated with the volume of the analyzed fluid.
Our study found statistically significant differences in volume distributions between certain TIS categories. Statistically lower volumes were observed in NFM compared to MAL, in UNCERTAIN (ND, AUS, SFM) compared to both MAL and NFM, and in NOT MAL (ND, NFM, AUS, SFM) compared to MAL. However, these differences were not substantial enough to hold any clinical relevance.
This study suggests that while fluid volume may slightly influence the TIS category, it does not impact the diagnostic accuracy of serous effusion cytology. Therefore, the ideal serous effusion specimen volume can be defined solely by practical parameters.
本研究旨在探讨使用国际浆液性液体细胞病理学报告系统（TIS）进行准确诊断所需的最佳浆液性液体量，以及提供浆液性积液病例在TIS分类（ND：非诊断性，NFM：恶性阴性，AUS：意义未明的非典型性，SFM：恶性可疑，MAL：恶性）中的分布信息及相关流行病学数据。
对2018年至2020年期间两家医院的2340例浆液性积液病例（胸腔、腹腔和心包腔）进行回顾性分析。为每个病例指定TIS分类，对于1181例病例，将这些分类与分析的液体量相关联。
我们的研究发现某些TIS分类之间在液体量分布上存在统计学显著差异。与MAL相比，NFM中的液体量在统计学上较低；与MAL和NFM相比，UNCERTAIN（ND、AUS、SFM）中的液体量在统计学上较低；与MAL相比，NOT MAL（ND、NFM、AUS、SFM）中的液体量在统计学上较低。然而，这些差异不足以具有任何临床相关性。
本研究表明，虽然液体量可能会对TIS分类产生轻微影响，但它不会影响浆液性积液细胞学的诊断准确性。因此，理想的浆液性积液标本量可以仅由实际参数来定义。
