Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen , Copenhagen, Denmark.
Global Health Research Unit for the Genomic Surveillance of Antimicrobial Resistance, Department of Pharmaceutical Microbiology, Faculty of Pharmacy, University of Ibadan , Ibadan, Oyo State, Nigeria.
Microbiol Spectr. 2023 Dec 12;11(6):e0238123. doi: 10.1128/spectrum.02381-23. Epub 2023 Oct 5.
is a leading cause of hospital-associated infections globally. reservoirs outside hospital settings are still unknown, and their occurrence in the environment is linked to clinical and anthropogenic activities. Although the risk of transmission of from environmental sources to humans is not fully understood, these sources pose significant risks for the continued dissemination of and their resistance traits. This study provides evidence that diverse and clinically relevant strains, many of which are resistant to carbapenems, are constantly being discharged into the environment through inadequately treated hospital wastewater. We further elucidate potential transmission routes between the environment and clinical infections and demonstrate the high prevalence of carbapenem resistance genes on highly mobile transposons among these strains. Our findings highlight the pressing need to address hospital wastewater as a crucial factor in curtailing the spread of carbapenem-resistant .
是全球医院相关感染的主要原因。医院环境以外的 储主仍然未知，其在环境中的出现与临床和人为活动有关。虽然从环境来源向人类传播 的风险尚不完全清楚，但这些来源对 和其耐药性特征的持续传播构成了重大风险。本研究表明，多样化且具有临床相关性的 菌株不断通过处理不当的医院废水排放到环境中，其中许多菌株对碳青霉烯类药物具有耐药性。我们进一步阐明了环境与临床感染之间的潜在传播途径，并证明了这些菌株中高度移动转座子上碳青霉烯类耐药基因的高流行率。我们的研究结果强调了必须将医院废水作为遏制碳青霉烯类耐药 传播的关键因素来处理。
