Zhang Xiaolei, Tang Fuyan, Shu Wei, Li Dongpeng, Liu Yuying, Xiao Haibin, Zhou Jin, Li Ping
School of Chemistry and Chemical Engineering, Shandong University of Technology, Zibo 255000, P. R. China.
School of Life Sciences and Medicine, Shandong University of Technology, Zibo 255000, P. R. China.
Analyst. 2023 Oct 23;148(21):5303-5321. doi: 10.1039/d3an01289a.
Inflammation as an adaptive response underlies a wide variety of physiological and pathological processes. The progression of inflammation is closely intertwined with various bioactive molecules. To dissect the biological mechanisms and physiopathological functions of these molecules, exploitation of versatile detection mean is of great importance. Fluorescence imaging technique has been widely employed to track bioactive species in living systems. As a result, many small-molecule fluorescent probes for bioactive species in inflammatory disease have been developed. However, this interesting and frontier topic hasn't been systematically categorized. Therefore, in this review, we have generalized the construction strategies and biological imaging applications of small-molecule fluorescent probes for various bioactive species, including reactive oxygen/nitrogen/sulfur species, enzyme, mainly in arthritis, pneumonia and hepatitis. Moreover, the future challenges in constructing novel fluorescent probes for inflammatory disease are also present. This review will facilitate the comprehension of superior fluorescent probes for active molecules associated with inflammation.
炎症作为一种适应性反应，是多种生理和病理过程的基础。炎症的进展与各种生物活性分子密切相关。为了剖析这些分子的生物学机制和生理病理功能，开发多功能检测手段至关重要。荧光成像技术已被广泛用于追踪生物系统中的生物活性物质。因此，已经开发出许多用于炎症性疾病中生物活性物质的小分子荧光探针。然而，这个有趣的前沿话题尚未得到系统分类。因此，在本综述中，我们总结了用于各种生物活性物质的小分子荧光探针的构建策略和生物成像应用，包括活性氧/氮/硫物种、酶，主要涉及关节炎、肺炎和肝炎。此外，还提出了构建新型炎症性疾病荧光探针的未来挑战。本综述将有助于理解与炎症相关的活性分子的优质荧光探针。
