Deng Ruxi, Zhou Hong, Qin Qiaoxi, Ding Li, Song Xinran, Chang Meiqi, Chen Yu, Zhou Yang
Department of Ultrasound, Affiliated Hospital of Southwest Jiaotong University, The Third People's Hospital of Chengdu, Chengdu, Sichuan, 610031, China.
Department of Medical Ultrasound, Shanghai Tenth People's Hospital, Ultrasound Research and Education Institute, Shanghai Engineering Research Center of Ultrasound Diagnosis and Treatment, Tongji University Cancer Center, School of Medicine, Tongji University, Shanghai, 200072, P. R. China.
Adv Mater. 2024 Mar;36(9):e2307568. doi: 10.1002/adma.202307568. Epub 2023 Dec 14.
Piezocatalytic tumor therapy is an emerging reactive oxygen species (ROS)-generating therapeutic approach that relies on piezoelectric polarization under ultrasound (US) irradiation. Optimizing ROS production is a primary objective for enhancing treatment efficiency. In this study, oxygen-vacancy-rich Pd-integrated black barium titanate (BTO) nanoparticles are rationally engineered to boost the ROS generation efficiency via the introduction of Pd. Pd-catalyzed hydrogenation at low temperatures narrows the bandgap of BTO and reduces the recombination rate of electron-hole pairs. Furthermore, Pd has dual-enzyme-mimicking characteristics, including peroxidase- and catalase-mimicking activities, which further heighten the therapeutic efficacy by enhancing ROS production and reversing the hypoxic tumor microenvironment. Importantly, the dual enzymatic activity of Pd can be amplified by multiple redox processes sparked by the piezoelectric potential under US stimulation, resulting in bilaterally enhanced multienzyme-piezoelectric synergetic therapy. In vitro and in vivo results confirm high tumor inhibition in murine breast cancer cells. This work stresses the critical effects of defect engineering-optimized piezodynamic tumor therapy.
压电催化肿瘤治疗是一种新兴的产生活性氧（ROS）的治疗方法，它依赖于超声（US）照射下的压电极化。优化ROS生成是提高治疗效率的主要目标。在本研究中，通过引入钯（Pd）合理设计了富含氧空位的钯集成黑色钛酸钡（BTO）纳米颗粒，以提高ROS生成效率。Pd在低温下催化氢化可缩小BTO的带隙并降低电子-空穴对的复合率。此外，Pd具有双酶模拟特性，包括过氧化物酶和过氧化氢酶模拟活性，通过增强ROS生成和逆转缺氧肿瘤微环境进一步提高治疗效果。重要的是，Pd的双酶活性可通过超声刺激下的压电势引发的多个氧化还原过程放大，从而实现双侧增强的多酶-压电协同治疗。体外和体内结果证实对小鼠乳腺癌细胞具有高度的肿瘤抑制作用。这项工作强调了缺陷工程优化的压电动肿瘤治疗的关键作用。
