Li Shuao, He Ningning, Wu Xiaoyu, Chen Fang, Xue Qingwen, Li Shangyong, Zhao Cheng
Department of Abdominal Ultrasound, The Affiliated Hospital of Qingdao University, Qingdao, People's Republic of China.
School of Basic Medicine, Qingdao University, Qingdao, People's Republic of China.
Int J Nanomedicine. 2024 Nov 28;19:12769-12791. doi: 10.2147/IJN.S491816. eCollection 2024.
Sonodynamic therapy (SDT) utilizes specific sound waves to activate sonosensitizers, generating localized biological effects to eliminate tumor cells. With advancements in nanomedicine, the application of nano-acoustic sensitizers has significantly advanced the development of SDT. BaTiO (BTO), an inorganic nano-acoustic sensitizer, possesses light refraction characteristics and a high dielectric constant, and can generate an electric field under ultrasound (US) stimulation. With continuous progress in multidisciplinary fields of US research, scientists have developed various types of barium titanate nanoparticles (BTNPs) to further advance SDT research and applications in tumor therapy. In this review, we present recently proposed and representative BTNPs, including their pathways of action, such as the induction of tumor cell senescence, ferroptosis, and glutathione depletion to reshape the tumor microenvironment, as well as their surface modifications. Research indicates that the mechanisms of action of ultrasound-driven BTNPs in tumor therapy are multifaceted. These mechanisms, whether utilized individually or synergistically, offer a potent and targeted strategy for cancer treatment. Furthermore, we discuss the application of BTNPs in various tumor types. Finally, we summarize the current challenges and future prospects for the clinical translation of BTNPs.
声动力疗法（SDT）利用特定声波激活声敏剂，产生局部生物学效应以消除肿瘤细胞。随着纳米医学的发展，纳米声学敏化剂的应用显著推动了声动力疗法的发展。钛酸钡（BTO）作为一种无机纳米声学敏化剂，具有光折射特性和高介电常数，并且在超声（US）刺激下能够产生电场。随着超声研究多学科领域的不断进步，科学家们开发了各种类型的钛酸钡纳米颗粒（BTNPs），以进一步推进声动力疗法在肿瘤治疗中的研究和应用。在这篇综述中，我们介绍了最近提出的具有代表性的BTNPs，包括它们的作用途径，如诱导肿瘤细胞衰老、铁死亡和谷胱甘肽耗竭以重塑肿瘤微环境，以及它们的表面修饰。研究表明，超声驱动的BTNPs在肿瘤治疗中的作用机制是多方面的。这些机制，无论是单独使用还是协同使用，都为癌症治疗提供了一种有效且有针对性的策略。此外，我们还讨论了BTNPs在各种肿瘤类型中的应用。最后，我们总结了BTNPs临床转化目前面临的挑战和未来前景。
