Li Xiaoyan, Wang Ying, Cao Xinyue, Song Xinran, Chen Liang, Chang Meiqi, Chen Yu, Huang Bingcang
Department of Radiology, Gongli Hospital of Shanghai Pudong New Area, Shanghai, 200135, P. R. China.
Sino-French Cooperative Central Lab, Gongli Hospital of Shanghai Pudong New Area, Shanghai, 200135, P. R. China.
J Nanobiotechnology. 2025 May 3;23(1):331. doi: 10.1186/s12951-025-03411-0.
Reactive oxygen species (ROS)-mediated pyroptosis provides a robust strategy for overcoming apoptosis resistance in breast cancer therapy. Nevertheless, the low efficiency of pyroptosis remains an undeniable challenge. Overcoming this obstacle necessitates the creation of innovative approaches and nanocatalysts to boost ROS generation. Herein, the distinct lanthanum-doped BiFeO (La-BFO) piezoelectric nanozymes are rationally designed and engineered for the specific cell pyroptosis of breast cancer through inducing the amplified production of ROS and releasing La ions.
The introduction of La reduces the recombination rate of electron-hole pairs through narrowing the bandgap and creating the oxygen vacancy of BFO, improving the harmful ROS generation efficiency. Importantly, the released La ions robustly disrupt the lysosomal membrane, ultimately inducing cell pyroptosis, in combination with ROS-induced biological effect.
In vitro and in vivo antineoplastic results confirm the desirable therapeutic effect on combating tumor. Especially, the iron and bismuth elemental components endow the nanocomposites with dual-mode computed tomography/magnetic resonance imaging ability, guaranteeing the potential therapeutic guidance and monitoring.
活性氧（ROS）介导的细胞焦亡为克服乳腺癌治疗中的凋亡抗性提供了一种强有力的策略。然而，细胞焦亡效率低下仍然是一个不可否认的挑战。克服这一障碍需要创造创新方法和纳米催化剂来促进ROS的产生。在此，通过诱导ROS的放大产生和释放镧离子，合理设计并构建了独特的镧掺杂BiFeO（La-BFO）压电纳米酶，用于乳腺癌的特异性细胞焦亡。
镧的引入通过缩小带隙和产生BFO的氧空位降低了电子-空穴对的复合率，提高了有害ROS的产生效率。重要的是，释放的镧离子与ROS诱导的生物学效应相结合，强烈破坏溶酶体膜，最终诱导细胞焦亡。
体外和体内抗肿瘤结果证实了其对肿瘤的良好治疗效果。特别是，铁和铋元素成分赋予了纳米复合材料双模态计算机断层扫描/磁共振成像能力，确保了潜在的治疗指导和监测。
