Guangdong Key Laboratory for Genome Stability & Disease Prevention and Marshall Laboratory of Biomedical Engineering, Shenzhen University Medical School, Shenzhen, Guangdong 518060, China; College of Life Sciences, Institute of Life Sciences and Green Development, Hebei University, Baoding 071002, China.
Guangdong Key Laboratory for Genome Stability & Disease Prevention and Marshall Laboratory of Biomedical Engineering, Shenzhen University Medical School, Shenzhen, Guangdong 518060, China.
Biochim Biophys Acta Gene Regul Mech. 2023 Dec;1866(4):194992. doi: 10.1016/j.bbagrm.2023.194992. Epub 2023 Oct 4.
The forkhead box subfamily P (FOXP) of transcription factors, consisting of FOXP1, FOXP2, FOXP3, and FOXP4, is involved in the regulation of multisystemic functioning. Disruption of the transcriptional activity of FOXP proteins leads to neurodevelopmental disorders and immunological diseases, as well as the suppression or promotion of carcinogenesis. The transcriptional activities of FOXP proteins are directly or indirectly regulated by diverse post-translational modifications, including phosphorylation, ubiquitination, SUMOylation, acetylation, O-GlcNAcylation, and methylation. Here, we discuss how post-translational modifications modulate the multiple functions of FOXP proteins and examine the implications for tumorigenesis and cancer therapy.
叉头框亚家族 P（FOXP）转录因子，包括 FOXP1、FOXP2、FOXP3 和 FOXP4，参与多系统功能的调节。FOXP 蛋白转录活性的破坏导致神经发育障碍和自身免疫性疾病，以及致癌作用的抑制或促进。FOXP 蛋白的转录活性直接或间接地受到多种翻译后修饰的调节，包括磷酸化、泛素化、SUMO 化、乙酰化、O-GlcNAc 化和甲基化。在这里，我们讨论了翻译后修饰如何调节 FOXP 蛋白的多种功能，并探讨了其对肿瘤发生和癌症治疗的意义。
