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急性后极部多发性斑状脉络膜视网膜病变伴视网膜内液的不典型病例。

Atypical case of acute posterior multifocal placoid pigment epitheliopathy with intraretinal fluid.

机构信息

Ophthalmology Department, Hospital Pedro Hispano, Matosinhos, Portugal

Ophthalmology Department, Hospital Pedro Hispano, Matosinhos, Portugal.

出版信息

BMJ Case Rep. 2023 Oct 5;16(10):e255464. doi: 10.1136/bcr-2023-255464.

DOI:10.1136/bcr-2023-255464
PMID:37798044
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10565154/
Abstract

Acute posterior multifocal placoid pigment epitheliopathy is a rare inflammatory chorioretinopathy, classified as a white dot syndrome, in which ischaemia of the choriocapillaris leads to atrophy of the external retinal layers, including the retinal pigment epithelium.A male patient in his 20s presented with sudden severe loss of vision in the left eye. Funduscopy revealed with yellow placoid lesions in the macula and near periphery. Spectral-domain optical coherence tomography and fluorescein angiography revealed the presence of central intraretinal fluid in the left eye and multiple areas of macular ischaemia bilaterally. Treatment with oral corticosteroids was initiated, and the anatomical changes, including the intraretinal fluid, improved steadily over the following weeks.Although rare, the presence of subretinal or intraretinal fluid should not decrease the suspicion of acute posterior multifocal placoid pigment epitheliopathy. Reabsorption of the fluid is usually accompanied by the improvement of the remaining anatomical changes and the visual function.

摘要

急性后部多灶性斑状脉络膜视网膜病变是一种罕见的炎症性脉络膜视网膜病变,归类为白点综合征,其中脉络膜毛细血管缺血导致外视网膜层包括视网膜色素上皮层萎缩。一名 20 多岁的男性患者左眼突然出现严重视力丧失。眼底检查显示黄斑部和周边有黄色斑片状病变。频域光相干断层扫描和荧光素血管造影显示左眼存在中心性视网膜内液和双侧多处黄斑缺血。开始口服皮质类固醇治疗,随后几周内,包括视网膜内液在内的解剖结构变化稳定改善。虽然罕见,但存在视网膜下或视网膜内液不应降低对急性后部多灶性斑状脉络膜视网膜病变的怀疑。液体的吸收通常伴随着剩余解剖结构和视觉功能的改善。

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本文引用的文献

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Proposing a Neurotropic Etiology for Acute Posterior Multifocal Placoid Pigment Epitheliopathy and Relentless Placoid Chorioretinitis.提出急性后极部多灶性扁平色素上皮病变及顽固性扁平脉络膜视网膜病变的嗜神经病因学。
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Management of Acute Posterior Multifocal Placoid Pigment Epitheliopathy (APMPPE): Insights from Multimodal Imaging with OCTA.急性后极部多灶性鳞状色素上皮病变(APMPPE)的管理:光学相干断层扫描血管造影(OCTA)多模态成像的见解
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ACUTE POSTERIOR MULTIFOCAL PLACOID PIGMENT EPITHELIOPATHY AFTER IMMUNIZATION WITH MULTIPLE VACCINES.多种疫苗免疫接种后发生的急性后极部多灶性鳞状色素上皮病变
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Relentless Placoid Chorioretinitis: A Case Series of Successful Tapering of Systemic Immunosuppressants Achieved with Adalimumab.顽固性板层状脉络膜视网膜炎:使用阿达木单抗成功减量全身免疫抑制剂的病例系列
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OCT Angiography Imaging in Serpiginous Choroidopathy.匐行性脉络膜病变的光学相干断层扫描血管造影成像
Ophthalmol Retina. 2018 Apr;2(4):351-359. doi: 10.1016/j.oret.2017.07.023. Epub 2017 Oct 19.
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Acute Posterior Multifocal Placoid Pigment Epitheliopathy Complicated by Fatal Cerebral Vasculitis.急性后极部多发性斑状色素上皮病变合并致命性脑血管炎。
J Neuroophthalmol. 2019 Jun;39(2):260-267. doi: 10.1097/WNO.0000000000000750.
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Neurologic Complications of Acute Posterior Multifocal Placoid Pigment Epitheliopathy: A Case Series of 4 Patients.急性后极部多灶性色素上皮病变的神经系统并发症:4例病例系列
Neurohospitalist. 2018 Jul;8(3):146-151. doi: 10.1177/1941874417749379. Epub 2018 Jan 17.
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