Department of Molecular Biotechnology and Health Sciences, Molecular Imaging Centre, University of Torino, Via Nizza 52, 10126, Turin, Italy.
Institute of Biostructures and Bioimaging, National Research Council, Via Nizza 52, 10126, Turin, Italy.
Sci Rep. 2023 Oct 5;13(1):16747. doi: 10.1038/s41598-023-43031-y.
A new bismuth-based CT agent was synthesized through a facile synthesis strategy. The in vitro stability, toxicity and CT performance were evaluated. The in vivo imaging performance was investigated using three different doses (0.5, 1.2 and 5 mmol/kg) and the result obtained at 1.2 mmol/kg was compared with the clinically approved CT agent iopamidol at the same dosage.
一种新型基于铋的 CT 造影剂通过一种简便的合成策略合成。评估了其体外稳定性、毒性和 CT 性能。使用三种不同剂量（0.5、1.2 和 5 mmol/kg）进行体内成像性能研究，并将 1.2 mmol/kg 时的结果与相同剂量的临床批准的 CT 造影剂碘帕醇进行比较。
