探索一种新型碘基材料作为X射线成像研究中替代造影剂的潜力。

Exploring the Potential of a Novel Iodine-Based Material as an Alternative Contrast Agent in X-ray Imaging Studies.

作者信息

Bliznakova Kristina, Kolev Iliyan, Dukov Nikolay, Dimova Tanya, Bliznakov Zhivko

机构信息

Department of Medical Equipment Electronic and Information Technologies in Healthcare, Faculty of Public Health, Medical University of Varna, 9002 Varna, Bulgaria.

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University of Varna, 9002 Varna, Bulgaria.

出版信息

Materials (Basel). 2024 Apr 27;17(9):2059. doi: 10.3390/ma17092059.

DOI:10.3390/ma17092059

PMID:38730863

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11084318/

Abstract

BACKGROUND

Contrast-enhanced mammography is one of the new emerging imaging techniques used for detecting breast tissue lesions. Optimization of imaging protocols and reconstruction techniques for this modality, however, requires the involvement of physical phantoms. Their development is related to the use of radiocontrast agents. This study assesses the X-ray properties of a novel contrast material in clinical settings. This material is intended for experimental use with physical phantoms, offering an alternative to commonly available radiocontrast agents.

MATERIALS AND METHODS

The water-soluble sodium salt of the newly synthesized diiodine-substituted natural eudesmic acid, Sodium 2,6-DiIodo-3,4,5-TriMethoxyBenzoate [NaDITMB], has been investigated with respect to one of the most commonly applied radiocontrast medium in medical practice-Omnipaque. For this purpose, simulation and experimental studies were carried out with a computational phantom and a physical counterpart, respectively. Synthetic and experimental X-ray images were subsequently produced under varying beam kilovoltage peaks (kVps), and the proposed contrast material was evaluated.

RESULTS AND DISCUSSION

Simulation results revealed equivalent absorptions between the two simulated radiocontrast agents. Experimental findings supported these simulations, showing a maximum deviation of 3.7% between the image gray values of contrast materials for NaDITMB and Omnipaque solutions for a 46 kVp X-ray beam. Higher kVp X-ray beams show even smaller deviations in the mean grey values of the imaged contrast agents, with the NaDITMB solution demonstrating less than a 2% deviation compared to Omnipaque.

CONCLUSION

The proposed contrast agent is a suitable candidate for use in experimental work related to contrast-enhanced imaging by utilizing phantoms. It boasts the advantages of easy synthesis and is recognized for its safety, ensuring a secure environment for both the experimenter and the environment.

摘要

背景

对比增强乳腺摄影是用于检测乳腺组织病变的新兴成像技术之一。然而，这种成像方式的成像协议和重建技术的优化需要物理模型的参与。它们的开发与放射性对比剂的使用有关。本研究评估了一种新型对比材料在临床环境中的X射线特性。这种材料旨在用于物理模型的实验，为常用的放射性对比剂提供了一种替代方案。

材料与方法

对新合成的二碘取代天然桉叶酸的水溶性钠盐2,6 - 二碘 - 3,4,5 - 三甲氧基苯甲酸钠[NaDITMB]进行了研究，将其与医学实践中最常用的放射性对比剂之一欧乃派克进行比较。为此，分别使用计算模型和物理模型进行了模拟和实验研究。随后在不同的束流千伏峰值（kVp）下生成合成和实验X射线图像，并对所提出的对比材料进行了评估。