Gomez Catherine, Hallot Gauthier, Laurent Sophie, Port Marc
Laboratoire de Génomique, Bioinformatique et Chimie Moléculaire (EA 7528), Equipe Chimie Moléculaire, Conservatoire National des Arts et Métiers (CNAM), HESAM Université, 2 Rue Conté, 75003 Paris, France.
Service de Chimie Générale, Organique et Biomédicale, Laboratoire de RMN et d'Imagerie Moléculaire, Université de Mons, 19 Avenue Maistriau, B-7000 Mons, Belgium.
Pharmaceutics. 2021 Oct 26;13(11):1793. doi: 10.3390/pharmaceutics13111793.
Recent reviews described the efficient syntheses of metallic bismuth nanoparticles. Nevertheless, few studies have been published on the medical applications of these nanoparticles compared to the number of studies on the well-documented clinical use of the bismuth(III) complex. An analysis of the literature revealed the significant potential of metallic bismuth nanoparticles in different theranostic applications. In the diagnostic field, preclinical proofs of concept have been demonstrated for X-ray, photoacoustic and fluorescence imaging. In the therapeutic field, several preclinical studies have shown the potential of bismuth nanoparticles as X-ray radiosensitizers for use in radiotherapy and as photothermal agents for applications in near infrared phototherapy. The properties of these metallic bismuth nanoparticles as bactericidal, fungicidal, antiparasitic and antibiofilm agents have also been studied. Although information concerning the toxic effects of these nanoparticles has been collected, these data are insufficient when considering the immediate clinical use of these new nanoparticles.
近期的综述介绍了金属铋纳米颗粒的高效合成方法。然而，与大量关于铋（III）配合物临床应用的研究相比，关于这些纳米颗粒医学应用的研究报道较少。文献分析表明，金属铋纳米颗粒在不同的诊疗应用中具有巨大潜力。在诊断领域，已在临床前研究中证实了其在X射线、光声和荧光成像方面的概念验证。在治疗领域，多项临床前研究表明，铋纳米颗粒有潜力作为X射线放射增敏剂用于放射治疗，以及作为光热剂用于近红外光疗。这些金属铋纳米颗粒作为杀菌、杀真菌、抗寄生虫和抗生物膜剂的特性也已得到研究。尽管已经收集了有关这些纳米颗粒毒性作用的信息，但考虑到这些新型纳米颗粒的直接临床应用时，这些数据还不够充分。
