Stewart M J, Adriaenssens P I, Jarvie D R, Prescott L F
Ann Clin Biochem. 1979 Mar;16(2):89-95. doi: 10.1177/000456327901600118.
Methods for the estimation of plasma paracetamol which depend on acid hydrolysis to p-aminophenol without a prior extraction step also measure inactive metabolites which are present in high concentrations. The extent of the overestimate obtained with such methods was determined using 24 samples from patents after paracetamol overdosage. There was a positive error of between 40 and 700% compared with a high-performance liquid chromatography reference method which measured only unchanged paracetamol. These non-specific methods should not be used to determine the need for specific therapy in patients with paracetamol poisoning.
依赖酸水解生成对氨基酚且无需预先萃取步骤来估算血浆对乙酰氨基酚的方法，也会检测到高浓度存在的无活性代谢物。使用对乙酰氨基酚过量服用后患者的24份样本，确定了用此类方法所获得的高估程度。与仅测定未变化的对乙酰氨基酚的高效液相色谱参考方法相比，存在40%至700%的正误差。这些非特异性方法不应被用于确定对乙酰氨基酚中毒患者是否需要进行特异性治疗。
